KEGG   DRUG: Atorvastatin calcium
Entry
D02258                      Drug                                   
Name
Atorvastatin calcium (USP);
Atorvastatin calcium hydrate (JP18);
Atorvastatin calcium trihydrate;
Atorvaliq (TN);
Lipitor (TN)
Product
ATORVALIQ (CMP Pharma), LIPITOR (Parke-Davis Div of Pfizer), LIPITOR (Viatris Specialty LLC)
  Generic
ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (A-S Medication Solutions), ATORVASTATIN CALCIUM (Accord Healthcare), ATORVASTATIN CALCIUM (American Health Packaging), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Aphena Pharma Solutions - Tennessee), ATORVASTATIN CALCIUM (Ascend Laboratories), ATORVASTATIN CALCIUM (Aurobindo Pharma Limited), ATORVASTATIN CALCIUM (Biocon Pharma Inc.,), ATORVASTATIN CALCIUM (Biocon Pharma), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Bryant Ranch Prepack), ATORVASTATIN CALCIUM (Cadila Pharmaceuticals Limited), ATORVASTATIN CALCIUM (Camber Pharmaceuticals), ATORVASTATIN CALCIUM (Cardinal Health 107), ATORVASTATIN CALCIUM (Cipla USA Inc.,), ATORVASTATIN CALCIUM (DIRECT RX), ATORVASTATIN CALCIUM (DIRECT RX), ATORVASTATIN CALCIUM (DirectRX), ATORVASTATIN CALCIUM (DirectRx), ATORVASTATIN CALCIUM (Direct_Rx), ATORVASTATIN CALCIUM (Direct_Rx), ATORVASTATIN CALCIUM (Direct_Rx), ATORVASTATIN CALCIUM (Direct_Rx), ATORVASTATIN CALCIUM (Dr. Reddy's Laboratories Limited), ATORVASTATIN CALCIUM (Dr. Reddy's Laboratories Limited), ATORVASTATIN CALCIUM (Dr. Reddy's Laboratories), ATORVASTATIN CALCIUM (Dr. Reddy's Laboratories), ATORVASTATIN CALCIUM (Golden State Medical Supply), ATORVASTATIN CALCIUM (Graviti Pharmaceuticals Private Limited), ATORVASTATIN CALCIUM (Lannett Company), ATORVASTATIN CALCIUM (Laurus Labs Limited), ATORVASTATIN CALCIUM (Lepu Pharmaceutical Technology), ATORVASTATIN CALCIUM (Lifestar Pharma LLC), ATORVASTATIN CALCIUM (Lupin Pharmaceuticals), ATORVASTATIN CALCIUM (MSN LABORATORIES PRIVATE LIMITED), ATORVASTATIN CALCIUM (Micro Labs Limited), ATORVASTATIN CALCIUM (Mylan Institutional), ATORVASTATIN CALCIUM (Mylan Pharmaceuticals), ATORVASTATIN CALCIUM (NIVAGEN PHARMACEUTICALS), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Northwind Pharmaceuticals), ATORVASTATIN CALCIUM (Novadoz Pharmaceuticals LLC), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (NuCare Pharmaceuticals), ATORVASTATIN CALCIUM (PD-Rx Pharmaceuticals), ATORVASTATIN CALCIUM (PD-Rx Pharmaceuticals), ATORVASTATIN CALCIUM (PD-Rx Pharmaceuticals), ATORVASTATIN CALCIUM (PD-Rx Pharmaceuticals), ATORVASTATIN CALCIUM (PD-Rx Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceutical), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Preferred Pharmaceuticals), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (Proficient Rx LP), ATORVASTATIN CALCIUM (QPharma), ATORVASTATIN CALCIUM (QPharma), ATORVASTATIN CALCIUM (QPharma), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (REMEDYREPACK), ATORVASTATIN CALCIUM (RPK Pharmaceuticals), ATORVASTATIN CALCIUM (RPK Pharmaceuticals), ATORVASTATIN CALCIUM (RPK Pharmaceuticals), ATORVASTATIN CALCIUM (RPK Pharmaceuticals), ATORVASTATIN CALCIUM (RPK Pharmaceuticals), ATORVASTATIN CALCIUM (RPK Pharmaceuticals), ATORVASTATIN CALCIUM (Radha Pharmaceuticals), ATORVASTATIN CALCIUM (Rising Pharma Holdings), ATORVASTATIN CALCIUM (ST. MARY'S MEDICAL PARK PHARMACY), ATORVASTATIN CALCIUM (ST. MARY'S MEDICAL PARK PHARMACY), ATORVASTATIN CALCIUM (ST. MARY'S MEDICAL PARK PHARMACY), ATORVASTATIN CALCIUM (ST. MARY'S MEDICAL PARK PHARMACY), ATORVASTATIN CALCIUM (ScieGen Pharmaceuticals), ATORVASTATIN CALCIUM (St Mary's Medical Park Pharmacy), ATORVASTATIN CALCIUM (St. Mary's Medical Park Pharmacy), ATORVASTATIN CALCIUM (Sun Pharmaceutical Industries), ATORVASTATIN CALCIUM (Teva Pharmaceuticals USA), ATORVASTATIN CALCIUM (Zydus Lifesciences Limited), ATORVASTATIN CALCIUM (Zydus Pharmaceuticals USA)
Formula
(C33H34FN2O5)2. 3H2O. Ca
Exact mass
1208.4846
Mol weight
1209.3876
Structure
Simcomp
Class
Hypolipidemic agent
 DG01946  Hypolipidemic agent
  DG01660  HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Transporter substrate
 DG01665  ABCB1 substrate
 DG01913  ABCG2 substrate
 DG02856  SLCO1B1 substrate
 DG02932  SLCO1B3 substrate
Remark
Therapeutic category: 2189
ATC code: C10AA05
Chemical structure group: DG00355
Product (DG00355): D07474<US> D02258<JP/US> D11095<US>
Product (mixture): D08488<JP/US> D10385<JP/US>
Efficacy
Antihyperlipidemic, HMG-CoA reductase inhibitor
  Disease
Hyperlipidemia [DS:H01635]
Hypercholesterolemia [DS:H00155]
Myocardial infarction [DS:H01730]
Angina [DS:H01632]
Target
HMGCR [HSA:3156] [KO:K00021]
  Pathway
hsa00900  Terpenoid backbone biosynthesis
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Transporter: ABCB1 [HSA:5243], ABCG2 [HSA:9429], SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234]
Interaction
Structure map
map07024  HMG-CoA reductase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C10 LIPID MODIFYING AGENTS
   C10A LIPID MODIFYING AGENTS, PLAIN
    C10AA HMG CoA reductase inhibitors
     C10AA05 Atorvastatin
      D02258  Atorvastatin calcium (USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Dyslipidemics, HMG CoA Reductase Inhibitors
   Atorvastatin
    D02258  Atorvastatin calcium (USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   218  Hyperlipidemia agents
    2189  Others
     D02258  Atorvastatin calcium (USP); Atorvastatin calcium hydrate (JP18)
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG00355  Atorvastatin
     D02258  Atorvastatin calcium
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00355  Atorvastatin
     D02258  Atorvastatin calcium
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00355  Atorvastatin
    D02258  Atorvastatin calcium
  DG01913  ABCG2 substrate
   DG00355  Atorvastatin
    D02258  Atorvastatin calcium
  DG02856  SLCO1B1 substrate
   DG00355  Atorvastatin
    D02258  Atorvastatin calcium
  DG02932  SLCO1B3 substrate
   DG00355  Atorvastatin
    D02258  Atorvastatin calcium
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01946  Hypolipidemic agent
   D02258  Atorvastatin calcium
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    HMGCR
     D02258  Atorvastatin calcium (USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D02258  Atorvastatin calcium hydrate
  D02258  Atorvastatin calcium tablets
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02258
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02258
 Drug transporters
  D02258
Drug groups [BR:br08330]
 Hypolipidemic agent
  DG01946  Hypolipidemic agent
   DG01660  HMG-CoA reductase inhibitor
    DG00355  Atorvastatin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00355  Atorvastatin
 Transporter substrate
  DG01665  ABCB1 substrate
   DG00355  Atorvastatin
  DG01913  ABCG2 substrate
   DG00355  Atorvastatin
  DG02856  SLCO1B1 substrate
   DG00355  Atorvastatin
  DG02932  SLCO1B3 substrate
   DG00355  Atorvastatin
Other DBs
CAS: 344423-98-9
PubChem: 7849317
ChEBI: 2911
LigandBox: D02258
NIKKAJI: J1.648.241B
KCF data

ATOM        86
            1   C8y C    22.6759  -21.0892
            2   C8y C    24.0739  -21.0892
            3   C8y C    24.4932  -19.7378
            4   N4y N    23.3749  -18.9456
            5   C8y C    22.2100  -19.7378
            6   C8y C    21.8371  -22.2075
            7   C1c C    25.7980  -19.3184
            8   C8y C    20.9052  -19.3184
            9   C1b C    23.3749  -17.5477
            10  C1b C    24.5865  -16.8487
            11  C1c C    24.5865  -15.4508
            12  O1a O    25.7980  -14.7519
            13  C1b C    23.3749  -14.7519
            14  C1c C    23.3749  -13.3539
            15  C1b C    24.5865  -12.6550
            16  O1a O    22.1634  -12.6550
            17  C6a C    25.9844  -12.6550
            18  O6a O    26.6834  -13.8666 #-
            19  O6a O    26.6834  -11.4435
            20  C8x C    20.6256  -17.9205
            21  C8x C    19.2743  -17.5011
            22  C8y C    18.2492  -18.4331
            23  C8x C    18.5288  -19.8310
            24  C8x C    19.8800  -20.2504
            25  C1a C    26.8697  -20.2504
            26  C1a C    26.1241  -17.9205
            27  X   F    16.8979  -18.0137
            28  C5a C    24.8881  -22.1939
            29  N1b N    26.2874  -22.1939
            30  O5a O    24.2674  -23.4227
            31  C8y C    26.9855  -23.4031
            32  C8x C    26.3066  -24.5794
            33  C8x C    27.0062  -25.7913
            34  C8x C    28.4055  -25.7912
            35  C8x C    29.0846  -24.6148
            36  C8x C    28.3848  -23.4030
            37  C8x C    20.4310  -22.1443
            38  C8x C    19.6783  -23.3240
            39  C8x C    20.3236  -24.6356
            40  C8x C    21.7318  -24.6282
            41  C8x C    22.4845  -23.4486
            42  Z   Ca   31.9955  -16.4087 #2+
            43  O0  O    33.3743  -18.9605
            44  C8y C    22.6759  -21.0892
            45  C8y C    24.0739  -21.0892
            46  C8y C    24.4932  -19.7378
            47  N4y N    23.3749  -18.9456
            48  C8y C    22.2100  -19.7378
            49  C8y C    20.9052  -19.3184
            50  C8x C    20.6256  -17.9205
            51  C8x C    19.2743  -17.5011
            52  C8y C    18.2492  -18.4331
            53  C8x C    18.5288  -19.8310
            54  C8x C    19.8800  -20.2504
            55  X   F    16.8979  -18.0137
            56  C1b C    23.3749  -17.5477
            57  C1b C    24.5865  -16.8487
            58  C1c C    24.5865  -15.4508
            59  O1a O    25.7980  -14.7519
            60  C1b C    23.3749  -14.7519
            61  C1c C    23.3749  -13.3539
            62  C1b C    24.5865  -12.6550
            63  C6a C    25.9844  -12.6550
            64  O6a O    26.6834  -13.8666 #-
            65  O6a O    26.6834  -11.4435
            66  O1a O    22.1634  -12.6550
            67  C1c C    25.7980  -19.3184
            68  C1a C    26.8697  -20.2504
            69  C1a C    26.1241  -17.9205
            70  C5a C    24.8881  -22.1939
            71  N1b N    26.2874  -22.1939
            72  C8y C    26.9855  -23.4031
            73  C8x C    26.3066  -24.5794
            74  C8x C    27.0062  -25.7913
            75  C8x C    28.4055  -25.7912
            76  C8x C    29.0846  -24.6148
            77  C8x C    28.3848  -23.4030
            78  O5a O    24.2674  -23.4227
            79  C8y C    21.8371  -22.2075
            80  C8x C    20.4310  -22.1443
            81  C8x C    19.6783  -23.3240
            82  C8x C    20.3236  -24.6356
            83  C8x C    21.7318  -24.6282
            84  C8x C    22.4845  -23.4486
            85  O0  O    33.3743  -18.9605
            86  O0  O    33.3743  -18.9605
BOND        88
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     1   6 1
            7     3   7 1
            8     5   8 1
            9     4   9 1
            10    9  10 1
            11   11  10 1 #Down
            12   11  12 1
            13   11  13 1
            14   13  14 1
            15   14  15 1
            16   14  16 1 #Up
            17   15  17 1
            18   17  18 1
            19   17  19 2
            20    8  20 2
            21   20  21 1
            22   21  22 2
            23   22  23 1
            24   23  24 2
            25    8  24 1
            26    7  25 1
            27    7  26 1
            28   22  27 1
            29    2  28 1
            30   28  29 1
            31   28  30 2
            32   29  31 1
            33   31  32 2
            34   32  33 1
            35   33  34 2
            36   34  35 1
            37   35  36 2
            38   31  36 1
            39    6  37 2
            40   37  38 1
            41   38  39 2
            42   39  40 1
            43   40  41 2
            44    6  41 1
            45   44  45 1
            46   45  46 2
            47   46  47 1
            48   47  48 1
            49   44  48 2
            50   44  79 1
            51   46  67 1
            52   48  49 1
            53   47  56 1
            54   56  57 1
            55   58  57 1 #Down
            56   58  59 1
            57   58  60 1
            58   60  61 1
            59   61  62 1
            60   61  66 1 #Up
            61   62  63 1
            62   63  64 1
            63   63  65 2
            64   49  50 2
            65   50  51 1
            66   51  52 2
            67   52  53 1
            68   53  54 2
            69   49  54 1
            70   67  68 1
            71   67  69 1
            72   52  55 1
            73   45  70 1
            74   70  71 1
            75   70  78 2
            76   71  72 1
            77   72  73 2
            78   73  74 1
            79   74  75 2
            80   75  76 1
            81   76  77 2
            82   72  77 1
            83   79  80 2
            84   80  81 1
            85   81  82 2
            86   82  83 1
            87   83  84 2
            88   79  84 1
BRACKET     1    16.2400  -26.0400   16.2400  -10.7100
            1    29.2600  -10.7100   29.2600  -26.0400
            1  2
 ORIGINAL  1    1   2   3   4   5   8  20  21  22  23  24  27   9  10  11  12
            1   13  14  15  17  18  19  16   7  25  26  28  29  31  32  33  34
            1   35  36  30   6  37  38  39  40  41
 REPEAT    1   44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59
            1   60  61  62  63  64  65  66  67  68  69  70  71  72  73  74  75
            1   76  77  78  79  80  81  82  83  84
            2    31.0800  -19.9500   31.0800  -17.9200
            2    34.0900  -17.9200   34.0900  -19.9500
            2  3
 ORIGINAL  2   43
 REPEAT    2   85  86

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