KEGG DRUG: Thiethylperazine

DRUG: Thiethylperazine

Entry

D02354                      Drug

Name

Thiethylperazine (USAN/INN)

Formula

C22H29N3S2

Exact mass

399.1803

Mol weight

399.6158

Structure

Simcomp

Class

Neuropsychiatric agent
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics

Remark

Same as:

C07132

ATC code:

R06AD03

Chemical structure group:

DG01102

Efficacy

Anti-emetic, Antipsychotic, Dopamine D2 receptor antagonist

Comment

Phenothiazine derivative

Target

DRD2 [HSA:1813] [KO:K04145]

Pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04728

Dopaminergic synapse

Interaction

Structure map

map07029

Antipsychotics - phenothiazines

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AD Phenothiazine derivatives
     R06AD03 Thiethylperazine
      D02354  Thiethylperazine (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine
     D02354  Thiethylperazine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02354  Thiethylperazine (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG01102  Thiethylperazine

Other DBs

CAS:

1420-55-9

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        27
            1   C8y C    28.6440  -19.9600
            2   N1y N    29.8570  -19.2568
            3   C8y C    28.6440  -21.3490
            4   C8x C    27.4310  -19.2568
            5   C8y C    31.0642  -19.9600
            6   S2x S    29.8570  -22.0579
            7   C8x C    27.4310  -22.0579
            8   C8x C    26.2179  -19.9600
            9   C8y C    31.0642  -21.3490
            10  C8x C    32.2714  -19.2568
            11  C8x C    26.2179  -21.3490
            12  C8x C    32.2714  -22.0579
            13  C8y C    33.4785  -19.9600
            14  C8x C    33.4785  -21.3490
            15  S2a S    34.6953  -19.2606
            16  C1b C    35.9177  -19.9698
            17  C1a C    37.1220  -19.2783
            18  C1b C    29.8580  -17.8253
            19  C1b C    31.0922  -17.1137
            20  C1b C    32.2806  -17.8001
            21  N1y N    33.4938  -17.1000
            22  C1x C    34.6721  -17.7806
            23  C1x C    35.8847  -17.0809
            24  N1y N    35.8849  -15.6809
            25  C1x C    34.7066  -15.0003
            26  C1x C    33.4941  -15.7000
            27  C1a C    37.1166  -14.9699
BOND        30
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12   10  13 2
            13   12  14 2
            14    6   9 1
            15    8  11 1
            16   13  14 1
            17   13  15 1
            18   15  16 1
            19   16  17 1
            20    2  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   21  26 1
            30   24  27 1

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (6)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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