KEGG   DRUG: Terbinafine
Entry
D02375                      Drug                                   
Name
Terbinafine (USAN/INN);
Lamasil (TN)
Formula
C21H25N
Exact mass
291.1987
Mol weight
291.4299
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
 DG02918  CYP2C8 substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Same as: C08079
ATC code: D01AE15 D01BA02
Chemical structure group: DG00375
Product (DG00375): D02219<JP/US>
Efficacy
Antifungal, Ergosterol biosynthesis inhibitor
Comment
Allylamine derivative
Target
squalene epoxidase [KO:K00511]
  Pathway
ko00100  Steroid biosynthesis
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP1A2 [HSA:1544], CYP3A4 [HSA:1576], CYP2C8 [HSA:1558], CYP2C19 [HSA:1557]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07026  Antifungal agents
map07114  Naphthalene family
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
   D01A ANTIFUNGALS FOR TOPICAL USE
    D01AE Other antifungals for topical use
     D01AE15 Terbinafine
      D02375  Terbinafine (USAN/INN)
   D01B ANTIFUNGALS FOR SYSTEMIC USE
    D01BA Antifungals for systemic use
     D01BA02 Terbinafine
      D02375  Terbinafine (USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Terbinafine
    D02375  Terbinafine (USAN/INN)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Terbinafine
    D02375  Terbinafine (USAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00375  Terbinafine
    D02375  Terbinafine
  DG02918  CYP2C8 substrate
   DG00375  Terbinafine
    D02375  Terbinafine
  DG01642  CYP2C9 substrate
   DG00375  Terbinafine
    D02375  Terbinafine
  DG01639  CYP2C19 substrate
   DG00375  Terbinafine
    D02375  Terbinafine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00375  Terbinafine
     D02375  Terbinafine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00375  Terbinafine
    D02375  Terbinafine
Antimicrobials [BR:br08307]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Other ergosterol biosynthesis inhibitor
    D02375  Terbinafine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02375
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG00375  Terbinafine
  DG02918  CYP2C8 substrate
   DG00375  Terbinafine
  DG01642  CYP2C9 substrate
   DG00375  Terbinafine
  DG01639  CYP2C19 substrate
   DG00375  Terbinafine
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00375  Terbinafine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG00375  Terbinafine
Antimicrobials abbreviations [BR:br08327]
 Antifungals
  Ergosterol biosynthesis inhibitor
   Other ergosterol biosynthesis inhibitor
    DG00375  Terbinafine
Other DBs
CAS: 91161-71-6
PubChem: 7849434
ChEBI: 9448
LigandBox: D02375
NIKKAJI: J126.310B
KCF data

ATOM        22
            1   C8x C     5.7400  -17.9200
            2   C8x C     5.7400  -19.3200
            3   C8x C     6.9524  -20.0200
            4   C8y C     8.1649  -19.3200
            5   C8y C     8.1649  -17.9200
            6   C8x C     6.9524  -17.2200
            7   C8x C     9.3773  -20.0200
            8   C8x C    10.5897  -19.3200
            9   C8x C    10.5897  -17.9200
            10  C8y C     9.3773  -17.2200
            11  C1b C     9.3773  -15.8200
            12  N1c N    10.5918  -15.1188
            13  C1b C    11.7883  -15.8098
            14  C1a C    10.5918  -13.7202
            15  C2b C    12.9751  -15.1246
            16  C2b C    14.1666  -15.8128
            17  C3b C    15.3560  -15.1261
            18  C3b C    16.5684  -14.4261
            19  C1d C    17.7808  -13.7261
            20  C1a C    18.9933  -13.0261
            21  C1a C    17.0780  -12.5087
            22  C1a C    18.4780  -14.9336
BOND        23
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12   10  11 1
            13   11  12 1
            14   12  13 1
            15   12  14 1
            16   13  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 3
            20   18  19 1
            21   19  20 1
            22   19  21 1
            23   19  22 1

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