| Entry |
|
|---|
| Name |
Primidolol (USAN/INN) |
|---|
| Formula |
C17H23N3O4
|
|---|
| Exact mass |
333.1689
|
|---|
| Mol weight |
333.3822
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
|
|---|
| Remark |
|
|---|
| Efficacy |
Anti-anginal, Antiarrhythmic, Antihypertensive, beta1-Adrenergic receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Brite |
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
D02389 Primidolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
D02389 Primidolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D02389 Primidolol (USAN/INN)
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 24
1 C8x C 19.3795 -21.0989
2 C8x C 19.3736 -19.6906
3 C8x C 18.1641 -21.8000
4 C8y C 18.1641 -18.9895
5 C8x C 16.9489 -21.0929
6 C8y C 16.9489 -19.6906
7 C1a C 15.7336 -18.9895
8 O2a O 18.0954 -17.5916
9 C1b C 19.3768 -16.8938
10 C1c C 20.5868 -17.5941
11 C1b C 21.7981 -16.8964
12 N1b N 23.0079 -17.5965
13 C1b C 24.2193 -16.8989
14 C1b C 25.4293 -17.5990
15 O1a O 20.5853 -18.9920
16 N4y N 26.6381 -16.9004
17 C8x C 27.8504 -17.6016
18 C8y C 29.0638 -16.9021
19 C8y C 29.0648 -15.5017
20 N4x N 27.8525 -14.8005
21 C8y C 26.6391 -15.5000
22 C1a C 30.2740 -17.6019
23 O5x O 25.4289 -14.8002
24 O5x O 30.2760 -14.8036
BOND 25
1 11 12 1
2 4 6 2
3 12 13 1
4 6 7 1
5 13 14 1
6 14 16 1
7 5 6 1
8 15 10 1
9 4 8 1
10 1 2 2
11 8 9 1
12 1 3 1
13 9 10 1
14 16 17 1
15 17 18 2
16 18 19 1
17 19 20 1
18 20 21 1
19 21 16 1
20 2 4 1
21 18 22 1
22 10 11 1
23 21 23 2
24 3 5 2
25 19 24 2
|
|---|
