| Entry |
|
|---|
| Name |
Maprotiline (USAN) |
|---|
| Formula |
C20H23N
|
|---|
| Exact mass |
277.1831
|
|---|
| Mol weight |
277.4033
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01729 Tetracyclic antidepressant
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00941): | D00818<JP> |
|
|---|
| Efficacy |
Antidepressant, Selective noradrenaline reuptake inhibitor (NRI) |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA21 Maprotiline
D02566 Maprotiline (USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00941 Maprotiline
D02566 Maprotiline
DG01729 Tetracyclic antidepressant
DG00941 Maprotiline
D02566 Maprotiline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00941 Maprotiline
D02566 Maprotiline
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D02566 Maprotiline (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D02566
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00941 Maprotiline
DG01729 Tetracyclic antidepressant
DG00941 Maprotiline
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00941 Maprotiline
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 21
1 C1x C 21.9568 -16.7489
2 C1x C 21.9568 -17.8749
3 C1z C 21.4642 -15.8341
4 C8y C 20.1975 -16.5378
5 C8y C 22.7309 -16.5378
6 C1b C 21.4642 -14.3563
7 C8y C 20.1975 -17.9452
8 C8x C 19.0012 -15.7637
9 C8y C 22.7309 -18.0156
10 C8x C 23.9976 -15.8341
11 C1b C 22.7309 -13.6525
12 C1y C 21.4642 -18.7193
13 C8x C 18.9308 -18.6490
14 C8x C 17.7345 -16.4674
15 C8x C 23.9272 -18.7193
16 C8x C 25.2643 -16.6082
17 C1b C 23.9272 -14.4266
18 C8x C 17.7345 -17.9452
19 C8x C 25.2643 -18.0156
20 N1b N 25.2643 -13.7229
21 C1a C 26.5310 -14.4266
BOND 24
1 1 2 1
2 3 4 1
3 3 5 1
4 3 6 1
5 4 7 1
6 4 8 2
7 5 9 2
8 5 10 1
9 6 11 1
10 7 12 1
11 7 13 2
12 8 14 1
13 9 15 1
14 10 16 2
15 11 17 1
16 13 18 1
17 15 19 2
18 17 20 1
19 20 21 1
20 9 12 1
21 14 18 2
22 16 19 1
23 2 12 1
24 1 3 1
|
|---|
