KEGG   DRUG: Iloperidone
Entry
D02666                      Drug                                   
Name
Iloperidone (USAN/INN);
Fanapt (TN)
Product
FANAPT (Vanda Pharmaceuticals)
  Generic
ILOPERIDONE (Mylan Pharmaceuticals), ILOPERIDONE (Taro Pharmaceuticals U.S.A.)
Formula
C24H27FN2O4
Exact mass
426.1955
Mol weight
426.4806
Structure
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03005  Serotonin-dopamine antagonist (SDA)
 DG03200  Antipsychotic agent
  DG03064  Atypical antipsychotic
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N05AX14
Product: D02666<US>
Efficacy
Antipsychotic
Comment
Risperidone derivative
Target
DRD2 [HSA:1813] [KO:K04145]
HTR2 [HSA:3356 3357 3358] [KO:K04157]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX14 Iloperidone
      D02666  Iloperidone (USAN/INN) <US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Iloperidone
    D02666  Iloperidone (USAN/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    D02666  Iloperidone
  DG03005  Serotonin-dopamine antagonist (SDA)
   D02666  Iloperidone
  DG03200  Antipsychotic agent
   DG03064  Atypical antipsychotic
    D02666  Iloperidone
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D02666  Iloperidone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D02666  Iloperidone
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02666  Iloperidone (USAN/INN) <US>
   Serotonin
    HTR2
     D02666  Iloperidone (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02666
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02666
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02666
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D02666
Other DBs
CAS: 133454-47-4
PubChem: 17396835
ChEBI: 65173
LigandBox: D02666
NIKKAJI: J550.684K
KCF data

ATOM        31
            1   O2x O    20.8600  -29.1900
            2   C8y C    21.2800  -30.5200
            3   C8y C    22.6800  -30.5200
            4   C8y C    23.1000  -29.1900
            5   N5x N    21.9800  -28.3500
            6   C1x C    24.2900  -27.0900
            7   C1y C    24.2900  -28.4900
            8   C1x C    25.4800  -29.1900
            9   C1x C    26.7400  -28.4900
            10  N1y N    26.7400  -27.0900
            11  C1x C    25.4800  -26.3900
            12  C8x C    20.5800  -31.7324
            13  C8y C    21.2800  -32.9449
            14  C8x C    22.6800  -32.9449
            15  C8x C    23.3800  -31.7324
            16  X   F    20.5690  -34.1760
            17  C1b C    27.9466  -26.3800
            18  C1b C    29.1563  -27.0653
            19  C1b C    30.3766  -26.3470
            20  O2a O    31.5858  -27.0313
            21  C8y C    32.7852  -26.3249
            22  C8y C    33.9824  -27.0024
            23  C8x C    35.1888  -26.2920
            24  C8y C    35.1768  -24.8921
            25  C8x C    33.9796  -24.2146
            26  C8x C    32.7732  -24.9249
            27  C5a C    36.3949  -24.1743
            28  C1a C    37.6068  -24.8596
            29  O5a O    36.3821  -22.7501
            30  O2a O    33.9250  -28.4193
            31  C1a C    32.7046  -29.0596
BOND        34
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 2
            5     1   5 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11    6  11 1
            12    7   4 1
            13    2  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    3  15 2
            18   13  16 1
            19   10  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   21  26 1
            30   24  27 1
            31   27  28 1
            32   27  29 2
            33   22  30 1
            34   30  31 1

» Japanese version   » Back

  All links  
Ontology (8)   
   KEGG BRITE (8)   
Drug (6)   
   KEGG DGROUP (5)   
   LigandBox (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (6)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (4)   
All databases (23)   

Download RDF
DBGET integrated database retrieval system