KEGG   DRUG: Iloprost
Entry
D02721                      Drug                                   
Name
Iloprost (USAN/INN);
Ventavis (TN)
Product
VENTAVIS (Actelion Pharmaceuticals US)
Formula
C22H32O4
Exact mass
360.2301
Mol weight
360.4871
Structure
Simcomp
Class
Blood modifier agent
 DG01950  Antithrombotic agent
  DG01712  Antiplatelet agent
Hormonal agent
 DG01961  Prostaglandin derivative
  DG01810  Prostacycline derivative
Remark
Therapeutic category: 2190
ATC code: B01AC11
Chemical structure group: DG00158
Product (DG00158): D02721<JP/US>
Efficacy
Antihypertensive, Platelet aggregation inhibitor, Prostaglandin I2 receptor agonist
  Disease
Pulmonary arterial hypertension [DS:H01621]
Comment
Prostacycline derivative
Treatment of pulmonary hypertension
Target
PTGIR [HSA:5739] [KO:K04263]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04611  Platelet activation
Interaction
Structure map
map07034  Eicosanoids
map07228  Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC11 Iloprost
      D02721  Iloprost (USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Prostacyclin Vasodilators
    Iloprost
     D02721  Iloprost (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D02721  Iloprost (USAN/INN)
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01712  Antiplatelet agent
    DG00158  Iloprost
     D02721  Iloprost
 Hormonal agent
  DG01961  Prostaglandin derivative
   DG01810  Prostacycline derivative
    DG00158  Iloprost
     D02721  Iloprost
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostacyclin
    PTGIR
     D02721  Iloprost (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02721
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02721
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02721
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02721
Drug groups [BR:br08330]
 Blood modifier agent
  DG01950  Antithrombotic agent
   DG01712  Antiplatelet agent
    DG00158  Iloprost
 Hormonal agent
  DG01961  Prostaglandin derivative
   DG01810  Prostacycline derivative
    DG00158  Iloprost
Other DBs
CAS: 78919-13-8
PubChem: 17396888
ChEBI: 63916
LigandBox: D02721
NIKKAJI: J685.840F
KCF data

ATOM        26
            1   C1x C     8.0500  -25.0600
            2   C1y C     8.8900  -26.1800
            3   C1y C    10.2200  -25.6900
            4   C1y C    10.2200  -24.2900
            5   C1y C     8.8900  -23.8700
            6   O1a O     8.4000  -27.5100
            7   C1x C    11.0600  -23.1700
            8   C2y C    10.2200  -22.0500
            9   C1x C     8.8900  -22.4700
            10  C2b C    11.4800  -26.3900
            11  C2b C    12.6700  -25.6900
            12  C1c C    13.8600  -26.3900
            13  C1c C    15.0500  -25.7600
            14  C1b C    16.2400  -26.3900
            15  C1a C    15.0500  -24.2900
            16  C3b C    17.4300  -25.7600
            17  C3b C    18.6900  -25.0600
            18  C1a C    19.8800  -24.3600
            19  O1a O    13.8600  -27.8600
            20  C2b C    10.6480  -20.7170
            21  C1b C     9.7055  -19.6775
            22  C1b C     8.3621  -19.9679
            23  C1b C     7.3986  -18.9047
            24  C6a C     6.0516  -19.1956
            25  O6a O     5.0897  -18.1338
            26  O6a O     5.6246  -20.5230
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     2   6 1 #Down
            7     4   7 1 #Down
            8     7   8 1
            9     8   9 1
            10    5   9 1 #Down
            11    3  10 1 #Up
            12   10  11 2
            13   11  12 1
            14   12  13 1
            15   13  14 1
            16   13  15 1
            17   14  16 1
            18   16  17 3
            19   17  18 1
            20   12  19 1 #Down
            21    8  20 2
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   24  26 2

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