KEGG   DRUG: Bimatoprost
Entry
D02724                      Drug                                   
Name
Bimatoprost (JAN/USAN/INN);
Lumigan (TN);
Latisse (TN)
Product
  Generic
Formula
C25H37NO4
Exact mass
415.2723
Mol weight
415.5656
Structure
Class
Hormonal agent
 DG01961  Prostaglandin derivative
  DG01960  Prostaglandin F derivative
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
Therapeutic category: 1319 2679
ATC code: S01EE03
Chemical structure group: DG03267
Product (DG03267): D02724<JP/US>
Efficacy
Antiglaucoma, Eyelash growth stimulant
  Disease
Open angle glaucoma [DS:H00612]
Comment
Prostamide analog
Target
PTGFR [HSA:5737] [KO:K04262]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Structure map
map07035  Prostaglandins
map07054  Antiglaucoma agents
map07228  Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE03 Bimatoprost
      D02724  Bimatoprost (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatological Agents, Other
   Dermatological Agents, Miscellaneous
    Bimatoprost
     D02724  Bimatoprost (JAN/USAN/INN)
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Prostaglandin and Prostamide Analogs, Ophthalmic
    Bimatoprost
     D02724  Bimatoprost (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D02724  Bimatoprost (JAN/USAN/INN)
 2  Agents affecting individual organs
  26  Epidermides
   267  Hair remedies
    2679  Others
     D02724  Bimatoprost (JAN/USAN/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01961  Prostaglandin derivative
   DG01960  Prostaglandin F derivative
    DG03267  Bimatoprost
     D02724  Bimatoprost
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG03267  Bimatoprost
    D02724  Bimatoprost
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D02724  Bimatoprost
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    PTGFR
     D02724  Bimatoprost (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02724
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02724
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02724
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02724
Drug groups [BR:br08330]
 Hormonal agent
  DG01961  Prostaglandin derivative
   DG01960  Prostaglandin F derivative
    DG03267  Bimatoprost
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG03267  Bimatoprost
Other DBs
CAS: 155206-00-1
PubChem: 17396891
ChEBI: 51230
PDB-CCD: 15M[PDBj]
LigandBox: D02724
KCF data

ATOM        30
            1   C1y C    11.4800  -17.9900
            2   C1y C    11.4800  -16.5900
            3   C1y C    10.1485  -16.1574
            4   C1x C     9.3256  -17.2900
            5   C1y C    10.1485  -18.4226
            6   O1a O     9.7197  -14.8378
            7   O1a O     9.7197  -19.7422
            8   C1b C    12.6924  -15.8900
            9   C2b C    13.9049  -16.5900
            10  C2b C    12.6924  -18.6900
            11  C2b C    13.9049  -17.9900
            12  C1c C    15.1173  -18.6900
            13  C1b C    16.3297  -17.9900
            14  C1b C    17.5422  -18.6900
            15  C2b C    15.3049  -16.5900
            16  C1b C    16.5424  -15.8900
            17  C1b C    17.7549  -16.5900
            18  C1b C    18.9673  -15.8900
            19  C5a C    20.1797  -16.5900
            20  N1b N    21.3922  -15.8900
            21  C1b C    22.6046  -16.5900
            22  O1a O    15.1173  -20.0900
            23  C8y C    17.5422  -20.0900
            24  C8x C    16.3508  -20.7781
            25  C8x C    16.3510  -22.1781
            26  C8x C    17.5636  -22.8779
            27  C8x C    18.7550  -22.1898
            28  C8x C    18.7547  -20.7898
            29  O5a O    20.1797  -17.9899
            30  C1a C    23.8211  -15.8877
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     3   6 1 #Down
            7     5   7 1 #Down
            8     2   8 1 #Down
            9     8   9 1
            10    1  10 1 #Up
            11   10  11 2
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15    9  15 2
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   20  21 1
            22   12  22 1 #Down
            23   14  23 1
            24   23  24 2
            25   24  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   23  28 1
            30   19  29 2
            31   21  30 1

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