KEGG   DRUG: Asenapine maleate
Entry
D02995                      Drug                                   
Name
Asenapine maleate (JAN/USAN);
Saphris (TN)
Product
SAPHRIS (Allergan)
  Generic
ASENAPINE (Alembic Pharmaceuticals Limited), ASENAPINE (Alembic Pharmaceuticals), ASENAPINE (Breckenridge Pharmaceutical), ASENAPINE (Greenstone LLC), ASENAPINE (MSN LABORATORIES PRIVATE LIMITED), ASENAPINE (Sigmapharm Laboratories)
Formula
C17H16ClNO. C4H4O4
Exact mass
401.103
Mol weight
401.8402
Structure
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Metabolizing enzyme substrate
 DG01892  CYP1A2 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 1179
ATC code: N05AH05
Chemical structure group: DG03100
Product (DG03100): D11769<US> D02995<JP/US>
Efficacy
Antipsychotic
  Disease
Schizophrenia [DS:H01649]
Bipolar I disorder [DS:H01653]
Comment
Treatment of psychosis
Target
HTR1A [HSA:3350] [KO:K04153]
HTR2A [HSA:3356] [KO:K04157]
HTR2C [HSA:3358] [KO:K04157]
HTR6 [HSA:3362] [KO:K04162]
HTR7 [HSA:3363] [KO:K04163]
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines, thiazepines and oxepines
     N05AH05 Asenapine
      D02995  Asenapine maleate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Asenapine
    D02995  Asenapine maleate (JAN/USAN)
 Bipolar Agents
  Bipolar Agents, Other
   Asenapine
    D02995  Asenapine maleate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D02995  Asenapine maleate (JAN/USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG03100  Asenapine
     D02995  Asenapine maleate
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG03100  Asenapine
    D02995  Asenapine maleate
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG03100  Asenapine
    D02995  Asenapine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D02995  Asenapine maleate (JAN/USAN) <JP/US>
   Serotonin
    HTR1A
     D02995  Asenapine maleate (JAN/USAN) <JP/US>
    HTR2A
     D02995  Asenapine maleate (JAN/USAN) <JP/US>
    HTR2C
     D02995  Asenapine maleate (JAN/USAN) <JP/US>
    HTR6
     D02995  Asenapine maleate (JAN/USAN) <JP/US>
    HTR7
     D02995  Asenapine maleate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D02995
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D02995
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D02995
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D02995
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D02995
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG03100  Asenapine
 Metabolizing enzyme substrate
  DG01892  CYP1A2 substrate
   DG03100  Asenapine
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   DG03100  Asenapine
Other DBs
CAS: 85650-56-2
PubChem: 17397151
ChEBI: 71245
LigandBox: D02995
NIKKAJI: J349.614G
KCF data

ATOM        28
            1   C8y C    13.9474  -15.0494
            2   C1y C    14.8548  -16.0964
            3   C1y C    16.2507  -16.0964
            4   C8y C    17.0882  -14.9797
            5   C8y C    14.2267  -13.6535
            6   C8y C    16.7392  -13.6535
            7   O2x O    15.4829  -13.0254
            8   C8x C    17.7861  -12.6764
            9   C8x C    19.1123  -13.0254
            10  C8x C    19.4612  -14.4213
            11  C8x C    18.4143  -15.3984
            12  C8x C    12.6214  -15.4682
            13  C8y C    11.5744  -14.5608
            14  C8x C    11.8536  -13.1650
            15  C8x C    13.1798  -12.7462
            16  C1x C    16.7392  -17.4224
            17  N1y N    15.6225  -18.2600
            18  C1x C    14.4360  -17.4224
            19  X   Cl   10.2483  -14.9797
            20  C1a C    15.6225  -19.6559
            21  O6a O    21.2759  -16.2359
            22  C6a C    22.6019  -16.2359
            23  O6a O    23.2999  -17.3526
            24  C2b C    23.2999  -15.0494
            25  C2b C    24.9052  -15.0494
            26  C6a C    25.6032  -16.2359
            27  O6a O    26.9990  -16.2359
            28  O6a O    24.9750  -17.4224
BOND        30
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     6   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    4  11 2
            13    1  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    5  15 2
            18    3  16 1
            19   16  17 1
            20   17  18 1
            21    2  18 1
            22   13  19 1
            23   17  20 1
            24   21  22 1
            25   22  23 2
            26   22  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   26  28 1

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Ontology (10)   
   KEGG BRITE (10)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
Gene (11)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (6)   
All databases (29)   

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