KEGG   DRUG: Azacitidine
Entry
D03021                      Drug                                   
Name
Azacitidine (JAN/USAN/INN);
Vidaza (TN)
Product
AZACITIDINE (BluePoint Laboratories), ONUREG (Celgene Corporation), VIDAZA (Celgene Corporation)
  Generic
AZACITIDINE (Accord Healthcare), AZACITIDINE (Amneal Pharmaceuticals LLC), AZACITIDINE (Apotex Corp), AZACITIDINE (Armas Pharmaceuticals), AZACITIDINE (BluePoint Laboratories), AZACITIDINE (CELLTRION USA), AZACITIDINE (Cipla USA), AZACITIDINE (Dr. Reddy's Laboratories), AZACITIDINE (Dr. Reddy's Laboratories), AZACITIDINE (Dr. Reddy's Laboratories), AZACITIDINE (Dr. Reddy's Laboratories), AZACITIDINE (Eugia US LLC), AZACITIDINE (Fresenius Kabi USA), AZACITIDINE (Hikma Pharmaceuticals USA), AZACITIDINE (Meitheal Pharmaceuticals), AZACITIDINE (Meitheal Pharmaceuticals), AZACITIDINE (NorthStar RxLLC), AZACITIDINE (NorthStar RxLLC), AZACITIDINE (Panacea Biotec Limited), AZACITIDINE (Pilnova Pharma), AZACITIDINE (Sandoz), AZACITIDINE (Sandoz), AZACITIDINE (Wockhardt USA LLC.), AZACITIDINE FOR (Cipla USA)
Formula
C8H12N4O5
Exact mass
244.0808
Mol weight
244.2047
Structure
Simcomp
Remark
Same as: C11262
Therapeutic category: 4291
ATC code: L01BC07
Product: D03021<JP/US>
Efficacy
Antineoplastic, Antimetabolite
  Disease
Myelodysplastic syndrome [DS:H01481]
Comment
Cytidine [CPD:C00475] analog
Target
DNMT [HSA:1786 1788 1789] [KO:K00558 K17398 K17399]
  Pathway
hsa00270  Cysteine and methionine metabolism
hsa05206  MicroRNAs in cancer
Interaction
Structure map
map07041  Antineoplastics - antimetabolic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01B ANTIMETABOLITES
    L01BC Pyrimidine analogues
     L01BC07 Azacitidine
      D03021  Azacitidine (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antimetabolites
   Azacitidine
    D03021  Azacitidine (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D03021  Azacitidine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Methyltransferases
    DNMT
     D03021  Azacitidine (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03021
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03021
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03021
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03021
Other DBs
CAS: 320-67-2
PubChem: 17397176
ChEBI: 2038
PDB-CCD: 5AE[PDBj]
LigandBox: D03021
NIKKAJI: J1.523G
KCF data

ATOM        17
            1   C1y C    18.3340  -16.0895
            2   N4y N    19.6665  -15.6575
            3   C1y C    17.9014  -17.4167
            4   O2x O    17.1998  -15.2653
            5   C1y C    16.4982  -17.4167
            6   C1y C    16.0656  -16.0895
            7   O1a O    15.6799  -18.5506
            8   C1b C    14.7328  -15.6569
            9   O1a O    13.6982  -16.5982
            10  O1a O    18.7229  -18.5485
            11  C8x C    19.6636  -14.2586
            12  C8y C    20.8795  -16.3543
            13  N5x N    22.0894  -15.6524
            14  C8y C    22.0865  -14.2536
            15  N5x N    20.8736  -13.5567
            16  O5x O    20.8822  -17.7618
            17  N1a N    23.2968  -13.5514
BOND        18
            1     1   2 1 #Up
            2     1   3 1
            3     1   4 1
            4     3   5 1
            5     4   6 1
            6     5   7 1 #Down
            7     6   8 1 #Up
            8     8   9 1
            9     5   6 1
            10    3  10 1 #Down
            11    2  11 1
            12    2  12 1
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   11  15 2
            17   12  16 2
            18   14  17 1

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   KEGG BRITE (8)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
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Drug (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (7)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (6)   
   KEGG ORTHOLOGY (3)   
   KEGG GENES (3)   
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