KEGG   DRUG: Desloratadine
Entry
D03693                      Drug                                   
Name
Desloratadine (JAN/USP/INN);
Clarinex (TN)
Product
CLARINEX (Organon LLC)
  Generic
DESLORATADINE (A-S Medication Solutions), DESLORATADINE (A-S Medication Solutions), DESLORATADINE (A-S Medication Solutions), DESLORATADINE (Belcher Pharmaceuticals), DESLORATADINE (Bionpharma), DESLORATADINE (Bryant Ranch Prepack), DESLORATADINE (Dr. Reddy's Laboratories Limited), DESLORATADINE (Lupin Pharmaceuticals), DESLORATADINE (Virtus Pharmaceuticals)
Formula
C19H19ClN2
Exact mass
310.1237
Mol weight
310.8206
Structure
Simcomp
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01482  Histamine receptor H1 antagonist
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 4490
ATC code: R06AX27
Product: D03693<JP/US>
Product (mixture): D10850<US>
Efficacy
Antiallergic, Antipruritic, H1 receptor antagonist
  Disease
Allergic rhinitis [DS:H01360]
Comment
Treatment of seasonal allergic rhinitis
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04750  Inflammatory mediator regulation of TRP channels
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AX Other antihistamines for systemic use
     R06AX27 Desloratadine
      D03693  Desloratadine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Antihistamines
   Histamine (H1) Receptor Antagonists, Mildly/Non-sedating
    Desloratadine
     D03693  Desloratadine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   449  Miscellaneous
    4490  Miscellaneous
     D03693  Desloratadine (JAN/USP/INN)
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    D03693  Desloratadine
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D03693  Desloratadine
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D03693  Desloratadine
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D03693  Desloratadine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D03693  Desloratadine (JAN/USP/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03693
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03693
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03693
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03693
Other DBs
CAS: 100643-71-8
PubChem: 17397787
ChEBI: 291342
PDB-CCD: Y5R[PDBj]
LigandBox: D03693
KCF data

ATOM        22
            1   C1x C    15.9600  -18.2700
            2   C8y C    15.1200  -17.1500
            3   C8y C    15.4000  -15.7500
            4   C2y C    16.7300  -15.1900
            5   C1x C    17.3600  -18.2700
            6   C8y C    17.9200  -15.8200
            7   C8y C    18.2700  -17.2200
            8   C8x C    14.4200  -14.8400
            9   C8x C    13.0900  -15.1900
            10  C8y C    12.7400  -16.5900
            11  C8x C    13.7200  -17.5000
            12  C8x C    19.6000  -17.6400
            13  C8x C    20.6500  -16.7300
            14  C8x C    20.3700  -15.3300
            15  N5x N    18.9700  -14.9100
            16  C2y C    16.7300  -13.7900
            17  X   Cl   11.3979  -16.9886
            18  C1x C    17.9424  -13.0900
            19  C1x C    17.9424  -11.6900
            20  N1x N    16.7300  -10.9900
            21  C1x C    15.5176  -11.6900
            22  C1x C    15.5176  -13.0900
BOND        25
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    4  16 2
            19   10  17 1
            20   16  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   16  22 1

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