KEGG   DRUG: Dexrazoxane
Entry
D03730                      Drug                                   
Name
Dexrazoxane (JAN/USAN/INN)
Product
  Generic
DEXRAZOXANE (Eugia US LLC)
Formula
C11H16N4O4
Exact mass
268.1172
Mol weight
268.2691
Structure
Simcomp
Remark
Therapeutic category: 3929
ATC code: V03AF02
Chemical structure group: DG01162
Product (DG01162): D03730<JP/US> D07807<US>
Efficacy
Antidote, Chelating agent
Comment
Detoxifying agent for antineoplastic treatment
Target
TOP2 [HSA:7153 7155] [KO:K03164]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 V VARIOUS
  V03 ALL OTHER THERAPEUTIC PRODUCTS
   V03A ALL OTHER THERAPEUTIC PRODUCTS
    V03AF Detoxifying agents for antineoplastic treatment
     V03AF02 Dexrazoxane
      D03730  Dexrazoxane (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Antineoplastic Adjuncts/Mitigators
   Dexrazoxane
    D03730  Dexrazoxane (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   392  Antidotes
    3929  Others
     D03730  Dexrazoxane (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Isomerases (EC5)
   DNA topoisomerase
    TOP2
     D03730  Dexrazoxane (JAN/USAN/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03730
Other DBs
CAS: 24584-09-6
PubChem: 17397819
ChEBI: 50223
LigandBox: D03730
NIKKAJI: J22.227E
KCF data

ATOM        19
            1   N1x N    11.0600  -20.0200
            2   C5x C    11.0600  -18.6200
            3   C1x C    12.2500  -17.9200
            4   N1y N    13.5100  -18.6200
            5   C1x C    13.5100  -20.0200
            6   C5x C    12.2500  -20.7200
            7   O5x O    12.2500  -22.1200
            8   O5x O     9.8700  -17.9200
            9   C1b C    14.7000  -17.9200
            10  C1c C    15.8900  -18.6200
            11  N1y N    17.0800  -17.9200
            12  C1x C    17.0800  -16.5200
            13  C5x C    18.3400  -15.8200
            14  N1x N    19.5300  -16.5200
            15  C5x C    19.5300  -17.9200
            16  C1x C    18.3400  -18.6200
            17  O5x O    20.7200  -18.6200
            18  O5x O    18.3400  -14.4200
            19  C1a C    15.8900  -20.0200
BOND        20
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     6   7 2
            8     2   8 2
            9     4   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   14  15 1
            16   15  16 1
            17   11  16 1
            18   15  17 2
            19   13  18 2
            20   10  19 1 #Up

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Ontology (5)   
   KEGG BRITE (5)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   NIKKAJI (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
All databases (16)   

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