KEGG   DRUG: Dienogest
Entry
D03799                      Drug                                   
Name
Dienogest (JAN/USAN/INN);
Endometrion (TN)
Formula
C20H25NO2
Exact mass
311.1885
Mol weight
311.418
Structure
Simcomp
Class
Hormonal agent
 DG02004  Progesterone
 DG01666  Progesterone receptor agonist
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 2499
ATC code: G03DB08
Product: D03799<JP>
Product (mixture): D10461<US>
Efficacy
Anti-endometriosis, Contraceptive, Replenisher (progesterone), Progesterone receptor agonist
Comment
Pregnadiene derivative
Target
NR3C3 (PGR) [HSA:5241] [KO:K08556]
  Pathway
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa04915  Estrogen signaling pathway
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
   G03D PROGESTOGENS
    G03DB Pregnadien derivatives
     G03DB08 Dienogest
      D03799  Dienogest (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D03799  Dienogest (JAN/USAN/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG02004  Progesterone
   D03799  Dienogest
  DG01666  Progesterone receptor agonist
   D03799  Dienogest
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D03799  Dienogest
Drug classes [BR:br08332]
 Endocrine and hormonal agent
  DG02004  Progesterone
   D03799  Dienogest
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C3 (PGR)
     D03799  Dienogest (JAN/USAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03799
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D03799
Other DBs
CAS: 65928-58-7
PubChem: 17397887
ChEBI: 70708
LigandBox: D03799
NIKKAJI: J23.763I
KCF data

ATOM        23
            1   C2y C    21.9420  -17.7494
            2   C1y C    23.0600  -18.4480
            3   C1x C    21.9420  -16.3519
            4   C2y C    20.6843  -18.4480
            5   C1y C    24.3178  -17.7494
            6   C1x C    23.0600  -19.7757
            7   C1x C    23.1299  -15.7230
            8   C2y C    20.6843  -19.7757
            9   C1x C    19.5664  -17.7494
            10  C1z C    24.3177  -16.4217
            11  C1x C    21.8722  -20.4744
            12  C2x C    19.5664  -20.4744
            13  C1x C    18.3785  -18.4480
            14  C5x C    18.3785  -19.7757
            15  O5x O    17.1906  -20.4744
            16  C1a C    24.3177  -14.7448
            17  C1x C    26.6235  -17.7494
            18  C1x C    26.6235  -16.4217
            19  C1z C    25.5055  -15.7929
            20  O1a O    25.5055  -14.1853
            21  C1b C    26.7168  -15.0936
            22  C3b C    28.1155  -15.0936
            23  N3a N    29.5155  -15.0936
BOND        26
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   6 1
            5     3   7 1
            6     4   8 1
            7     4   9 1
            8     6  11 1
            9     8  12 2
            10    9  13 1
            11   12  14 1
            12   14  15 2
            13    7  10 1
            14    8  11 1
            15   13  14 1
            16   10  16 1 #Up
            17   17  18 1
            18   18  19 1
            19   10  19 1
            20   19  20 1 #Up
            21    5  10 1
            22    5  17 1
            23    2   5 1
            24   19  21 1 #Down
            25   21  22 1
            26   22  23 3

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Chemical substance (3)   
   PubChem (1)   
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