KEGG   DRUG: Diethylpropion hydrochloride
Entry
D03801                      Drug                                   
Name
Diethylpropion hydrochloride (USP);
Tenuate (TN)
Product
  Generic
Formula
C13H19NO. HCl
Exact mass
241.1233
Mol weight
241.757
Structure
Simcomp
Class
Gastrointestinal agent
 DG01705  Anoretic
  DG01704  Phenethylamine anorexic
Remark
ATC code: A08AA03
Chemical structure group: DG00104
Product (DG00104): D03801<US>
Efficacy
Appetite suppressant
Comment
Diethylpropion is called Amfepramone in INN.
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA03 Amfepramone
      D03801  Diethylpropion hydrochloride (USP) <US>
USP drug classification [BR:br08302]
 Anti-Obesity Agents
  Diethylpropion
   D03801  Diethylpropion hydrochloride (USP)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00104  Amfepramone
     D03801  Diethylpropion hydrochloride
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D03801  Diethylpropion hydrochloride (USP) <US>
    SLC6A3 (DAT1)
     D03801  Diethylpropion hydrochloride (USP) <US>
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01705  Anoretic
   DG01704  Phenethylamine anorexic
    DG00104  Amfepramone
Other DBs
CAS: 134-80-5
PubChem: 17397889
ChEBI: 643703
LigandBox: D03801
NIKKAJI: J472.997H
KCF data

ATOM        16
            1   C8y C    11.2700  -16.5200
            2   C5a C    12.4600  -15.8200
            3   C8x C    10.0800  -15.8200
            4   C8x C    11.2700  -17.9200
            5   C1c C    13.7200  -16.5200
            6   O5a O    12.4600  -14.4200
            7   C8x C     8.8200  -16.5200
            8   C8x C    10.0800  -18.6200
            9   N1c N    14.9100  -15.8200
            10  C1a C    13.7200  -17.9200
            11  C8x C     8.8200  -17.9200
            12  C1b C    16.1000  -16.5200
            13  C1b C    14.9100  -14.4200
            14  C1a C    17.3600  -15.8200
            15  C1a C    16.1000  -13.7200
            16  X   Cl   18.1300  -18.4800
BOND        15
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     4   8 2
            8     5   9 1
            9     5  10 1
            10    7  11 2
            11    9  12 1
            12    9  13 1
            13   12  14 1
            14   13  15 1
            15    8  11 1

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