KEGG   DRUG: Dimethyl fumarate
Entry
D03846                      Drug                                   
Name
Dimethyl fumarate (JAN/USAN);
Tecfidera (TN)
Product
TECFIDERA (Biogen)
  Generic
DIMETHYL FUMARATE (A-S Medication Solutions), DIMETHYL FUMARATE (A-S Medication Solutions), DIMETHYL FUMARATE (Accord Healthcare), DIMETHYL FUMARATE (Amneal Pharmaceuticals NY LLC), DIMETHYL FUMARATE (Ascend Laboratories), DIMETHYL FUMARATE (Aurobindo Pharma Limited), DIMETHYL FUMARATE (Camber Pharmaceuticals), DIMETHYL FUMARATE (Cipla USA), DIMETHYL FUMARATE (Dr. Reddy's Laboratories), DIMETHYL FUMARATE (Glenmark Pharmaceuticals), DIMETHYL FUMARATE (Golden State Medical Supply), DIMETHYL FUMARATE (MSN LABORATORIES PRIVATE LIMITED), DIMETHYL FUMARATE (Mylan Pharmaceuticals), DIMETHYL FUMARATE (SOLA Pharmaceuticals), DIMETHYL FUMARATE (Solco Healthcare US), DIMETHYL FUMARATE (TEVA PHARMACEUTICALS USA), DIMETHYL FUMARATE (TWi Pharmaceuticals), DIMETHYL FUMARATE (Zydus Lifesciences Limited), DIMETHYL FUMARATE (Zydus Pharmaceuticals USA)
Formula
C6H8O4
Exact mass
144.0423
Mol weight
144.1253
Structure
Simcomp
Remark
Therapeutic category: 1190
ATC code: L04AX07
Product: D03846<JP/US>
Efficacy
Immunomodulator
  Disease
Multiple sclerosis [DS:H01490]
Target
KEAP1 [HSA:9817] [KO:K10456]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX07 Dimethyl fumarate
      D03846  Dimethyl fumarate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Multiple Sclerosis Agents
   Dimethyl Fumarate
    D03846  Dimethyl fumarate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D03846  Dimethyl fumarate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Not elsewhere classified
  Cellular process
   Ubiquitin system
    KEAP1
     D03846  Dimethyl fumarate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D03846
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D03846
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D03846
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D03846
Other DBs
CAS: 624-49-7
PubChem: 17397932
ChEBI: 76004
PDB-CCD: EOU[PDBj]
LigandBox: D03846
NIKKAJI: J45.019G
KCF data

ATOM        10
            1   C7a C    19.9506  -16.6590
            2   C2b C    21.1616  -17.3610
            3   O7a O    18.7397  -17.3610
            4   O6a O    19.9506  -15.2609
            5   C2b C    22.3784  -16.6590
            6   C7a C    23.5894  -17.3610
            7   O7a O    24.8003  -16.6590
            8   O6a O    23.5894  -18.7591
            9   C1a C    25.9991  -17.3484
            10  C1a C    17.5409  -16.6716
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     5   6 1
            6     6   7 1
            7     6   8 2
            8     7   9 1
            9     3  10 1

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Ontology (8)   
   KEGG BRITE (8)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   LigandBox (1)   
Chemical substance (5)   
   PubChem (1)   
   ChEBI (1)   
   HSDB (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (17)   

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