| Entry |
|
|---|
| Name |
Ropivacaine hydrochloride (USP);
Ropivacaine hydrochloride hydrate (JAN);
Anapeine (TN) |
|---|
| Product |
|
|---|
| Generic |
ROPIVACAINE HYDROCHLORIDE (Amneal Pharmaceuticals LLC), ROPIVACAINE HYDROCHLORIDE (Baxter Healthcare Corporation), ROPIVACAINE HYDROCHLORIDE (Baxter Healthcare Corporation), ROPIVACAINE HYDROCHLORIDE (Caplin Steriles Limited), ROPIVACAINE HYDROCHLORIDE (Civica), ROPIVACAINE HYDROCHLORIDE (Eugia US LLC), ROPIVACAINE HYDROCHLORIDE (Gland Pharma Limited), ROPIVACAINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), ROPIVACAINE HYDROCHLORIDE (Hospira), ROPIVACAINE HYDROCHLORIDE (NorthStar Rx LLC), ROPIVACAINE HYDROCHLORIDE (Sagent Pharmaceuticals), ROPIVACAINE HYDROCHLORIDE (Sagent Pharmaceuticals), ROPIVACAINE HYDROCHLORIDE (Somerset Therapeutics) |
|---|
| Formula |
C17H26N2O. HCl. H2O
|
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| Exact mass |
328.1918
|
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| Mol weight |
328.8774
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 1214 |
| Product (DG00806): | D04048<JP/US> |
|
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| Efficacy |
Anesthetic (local) |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01B ANESTHETICS, LOCAL
N01BB Amides
N01BB09 Ropivacaine
D04048 Ropivacaine hydrochloride (USP) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
12 Agents affecting peripheral nervous system
121 Local anesthetics
1214 Xylidines
D04048 Ropivacaine hydrochloride (USP); Ropivacaine hydrochloride hydrate (JAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00806 Ropivacaine
D04048 Ropivacaine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00806 Ropivacaine
D04048 Ropivacaine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00806 Ropivacaine
D04048 Ropivacaine hydrochloride
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN2A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN3A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN4A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN5A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN8A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN9A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN10A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
SCN11A
D04048 Ropivacaine hydrochloride (USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D04048
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04048
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00806 Ropivacaine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00806 Ropivacaine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00806 Ropivacaine
|
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| Other DBs |
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| KCF data |
ATOM 22
1 X Cl 31.2200 -18.2001
2 O0 O 31.7800 -21.0001
3 C8x C 20.8600 -18.3400
4 C8x C 20.8600 -19.7400
5 C8y C 22.0500 -20.4400
6 C8y C 23.3100 -19.7400
7 C8y C 23.3100 -18.3400
8 C8x C 22.0500 -17.6400
9 N1b N 24.5000 -20.4400
10 C5a C 25.6900 -19.7400
11 C1a C 24.5000 -17.6400
12 C1y C 26.9500 -20.4400
13 N1y N 26.9500 -21.8400
14 C1x C 28.1400 -22.5400
15 C1x C 29.3300 -21.8400
16 C1x C 29.3300 -20.4400
17 C1x C 28.1400 -19.7400
18 C1a C 22.0500 -21.8400
19 C1b C 25.6900 -22.5400
20 C1b C 24.5000 -21.8400
21 C1a C 23.3100 -22.5400
22 O5a O 25.6900 -18.3400
BOND 21
1 3 4 2
2 4 5 1
3 5 6 2
4 6 7 1
5 7 8 2
6 3 8 1
7 6 9 1
8 9 10 1
9 7 11 1
10 12 10 1 #Down
11 12 13 1
12 13 14 1
13 14 15 1
14 15 16 1
15 16 17 1
16 12 17 1
17 5 18 1
18 13 19 1
19 19 20 1
20 20 21 1
21 10 22 2
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