Entry |
|
Name |
Fenfluramine hydrochloride (JAN/USAN); Fintepla (TN); Pondimin (TN) |
Product |
|
Formula |
C12H16F3N. HCl
|
Exact mass |
267.1002
|
Mol weight |
267.7183
|
Structure |
|
Simcomp |
|
Class |
|
Remark |
Therapeutic category: | 1139 |
Product (DG00103): | D04148<JP/US> |
|
Efficacy |
Antiepileptic, Appetite suppressant |
Disease |
Dravet syndrome [DS: H01818] Lennox-Gastaut syndrome [DS: H01813] |
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
hsa05022 | Pathways of neurodegeneration - multiple diseases |
|
Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2B6 [HSA: 1555], CYP2D6 [HSA: 1565]; CYP2C9 [HSA: 1559], CYP2C19 [HSA: 1557], CYP3A4 [HSA: 1576], CYP3A5 [HSA: 1577]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
A08AA Centrally acting antiobesity products
A08AA02 Fenfluramine
D04148 Fenfluramine hydrochloride (JAN/USAN) <JP/US>
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AX Other antiepileptics
N03AX26 Fenfluramine
D04148 Fenfluramine hydrochloride (JAN/USAN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D04148 Fenfluramine hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01705 Anoretic
DG01704 Phenethylamine anorexic
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
DG02919 CYP2B6 substrate
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
DG01642 CYP2C9 substrate
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
DG01639 CYP2C19 substrate
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
DG01644 CYP2D6 substrate
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
DG02925 CYP3A5 substrate
DG00103 Fenfluramine
D04148 Fenfluramine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR1D
D04148 Fenfluramine hydrochloride (JAN/USAN) <JP/US>
HTR2A
D04148 Fenfluramine hydrochloride (JAN/USAN) <JP/US>
HTR2C
D04148 Fenfluramine hydrochloride (JAN/USAN) <JP/US>
Transporters
Solute carrier family
SLC6
SLC6A4 (HTT)
D04148 Fenfluramine hydrochloride (JAN/USAN) <JP/US>
Other transporters
Auxiliary transport proteins (TC:8.A)
SIGMAR1
D04148 Fenfluramine hydrochloride (JAN/USAN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D04148
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D04148
New drug approvals in the USA, Europe and Japan [br08328.html]
Approval dates by FDA, EMA and PMDA
D04148
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04148
Drug groups [BR:br08330]
Gastrointestinal agent
DG01705 Anoretic
DG01704 Phenethylamine anorexic
DG00103 Fenfluramine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00103 Fenfluramine
DG02919 CYP2B6 substrate
DG00103 Fenfluramine
DG01642 CYP2C9 substrate
DG00103 Fenfluramine
DG01639 CYP2C19 substrate
DG00103 Fenfluramine
DG01644 CYP2D6 substrate
DG00103 Fenfluramine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00103 Fenfluramine
DG02925 CYP3A5 substrate
DG00103 Fenfluramine
|
Other DBs |
|
KCF data |
ATOM 17
1 C8y C 16.3100 -16.0300
2 C8x C 15.1200 -15.3300
3 C8x C 16.3100 -17.4300
4 C1b C 17.5000 -15.3300
5 C8y C 13.8600 -16.0300
6 C8x C 15.1200 -18.1300
7 C1c C 18.7600 -16.0300
8 C8x C 13.8600 -17.4300
9 C1d C 12.6700 -15.3300
10 N1b N 19.9500 -15.3300
11 C1a C 18.7600 -17.4300
12 X F 11.3400 -14.5600
13 X F 12.0400 -16.3800
14 X F 13.4400 -14.2100
15 C1b C 21.2100 -16.0300
16 C1a C 22.4000 -15.3300
17 X Cl 23.3100 -17.7800
BOND 16
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 2
8 5 9 1
9 7 10 1
10 7 11 1
11 9 12 1
12 9 13 1
13 9 14 1
14 10 15 1
15 15 16 1
16 6 8 1
|