| Entry |
|
|---|
| Name |
Galantamine (USAN/INN);
Reminyl (TN) |
|---|
| Formula |
C17H21NO3
|
|---|
| Exact mass |
287.1521
|
|---|
| Mol weight |
287.3535
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Source |
Galanthus woronowii [TAX: 197699]
|
|---|
| Class |
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG01968 Antidementia agent
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00985): | D02173<JP/US> |
|
|---|
| Efficacy |
Dementia therapeutic agent, Acetylcholinesterase inhibitor |
|---|
| Comment |
Galanthus alkaloid
Alzheimer's disease treatment
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07056 | Agents for Alzheimer-type dementia |
| map07220 | Cholinergic and anticholinergic drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06D ANTI-DEMENTIA DRUGS
N06DA Anticholinesterases
N06DA04 Galantamine
D04292 Galantamine (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00985 Galantamine
D04292 Galantamine
DG01968 Antidementia agent
DG00985 Galantamine
D04292 Galantamine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00985 Galantamine
D04292 Galantamine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00985 Galantamine
D04292 Galantamine
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Carboxylic-ester hydrolases
ACHE
D04292 Galantamine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D04292
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01595 Cholinesterase inhibitor
DG01593 Acetylcholinesterase inhibitor
DG00985 Galantamine
DG01968 Antidementia agent
DG00985 Galantamine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00985 Galantamine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00985 Galantamine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 21
1 C8y C 26.6000 -12.1800
2 C1x C 27.6500 -12.9500
3 N1y N 28.9800 -12.6700
4 C1x C 29.5400 -11.4100
5 C8y C 26.6000 -10.7800
6 C1x C 28.9800 -10.2200
7 C1z C 27.6500 -9.7300
8 C1a C 29.8900 -13.7200
9 C8x C 25.4100 -12.8800
10 C8x C 24.2200 -12.1800
11 C8y C 24.2200 -10.7800
12 C8y C 25.4100 -10.0800
13 O2a O 23.0300 -10.1500
14 O2x O 25.7600 -8.4700
15 C1y C 27.1600 -8.4000
16 C1x C 27.7900 -7.2800
17 C1y C 29.1900 -7.2800
18 C2x C 29.8900 -8.4700
19 C2x C 29.1900 -9.7300
20 O1a O 29.8900 -6.0200
21 C1a C 21.8441 -10.8940
BOND 24
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 7 6 1 #Down
8 3 8 1
9 1 9 1
10 9 10 2
11 10 11 1
12 11 12 2
13 5 12 1
14 11 13 1
15 12 14 1
16 14 15 1
17 7 15 1
18 15 16 1
19 16 17 1
20 17 18 1
21 7 19 1
22 19 18 2
23 17 20 1 #Up
24 13 21 1
|
|---|
