KEGG   DRUG: Ganaxolone
Entry
D04300                      Drug                                   
Name
Ganaxolone (USAN/INN);
Ztalmy (TN)
Product
ZTALMY (Marinus Pharmaceuticals)
Formula
C22H36O2
Exact mass
332.2715
Mol weight
332.52
Structure
Simcomp
Class
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01639  CYP2C19 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
 DG02925  CYP3A5 substrate
Remark
ATC code: N03AX27
Product: D04300<US>
Efficacy
Antiepileptic, Antimigraine
  Disease
Seizures associated with cyclin-dependent kinase-like 5 deficiency disorder [DS:H01819]
Comment
Allopregnanolone [CPD:C15484] analog
Treatment of epilepsy and migraine
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP2B6 [HSA:1555], CYP2C19 [HSA:1557], CYP2D6 [HSA:1565]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AX Other antiepileptics
     N03AX27 Ganaxolone
      D04300  Ganaxolone (USAN/INN) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   GABA Agents, Other
    Ganaxolone
     D04300  Ganaxolone (USAN/INN)
Drug groups [BR:br08330]
 Metabolizing enzyme substrate
  DG02919  CYP2B6 substrate
   D04300  Ganaxolone
  DG01639  CYP2C19 substrate
   D04300  Ganaxolone
  DG01644  CYP2D6 substrate
   D04300  Ganaxolone
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D04300  Ganaxolone
  DG02925  CYP3A5 substrate
   D04300  Ganaxolone
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D04300  Ganaxolone (USAN/INN) <US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04300
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04300
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04300
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04300
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D04300
Other DBs
CAS: 38398-32-2
PubChem: 47206230
ChEBI: 177658
LigandBox: D04300
NIKKAJI: J805.191G
KCF data

ATOM        24
            1   C1x C    38.1743  -26.7423
            2   C1z C    38.1743  -28.1094
            3   C1x C    39.3363  -28.7930
            4   C1y C    40.5668  -28.1094
            5   C1z C    40.5668  -26.7423
            6   C1x C    39.3363  -26.0587
            7   C1x C    41.7288  -28.7930
            8   C1x C    42.8909  -28.1094
            9   C1y C    42.8909  -26.7423
            10  C1y C    41.7288  -26.0587
            11  C1y C    44.1213  -26.0587
            12  C1z C    44.1213  -24.6916
            13  C1x C    42.8909  -24.0080
            14  C1x C    41.7288  -24.6916
            15  C1a C    40.5668  -25.3751
            16  C1a C    44.1213  -23.3244
            17  C1a C    36.8071  -28.1094
            18  O1a O    37.8325  -29.4082
            19  C1x C    46.5138  -26.0587
            20  C1x C    46.5138  -24.6916
            21  C1y C    45.2834  -24.0080
            22  C5a C    45.2666  -22.6410
            23  C1a C    44.0870  -21.9792
            24  O5a O    46.4544  -21.9354
BOND        27
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    9  11 1
            13   12  13 1
            14   13  14 1
            15   10  14 1
            16    5  15 1 #Up
            17   12  16 1 #Up
            18    2  17 1 #Up
            19    2  18 1 #Down
            20   11  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1 #Up
            24   22  23 1
            25   22  24 2
            26   21  12 1
            27   12  11 1

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Disease (1)   
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Drug (6)   
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Chemical substance (3)   
   PubChem (1)   
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   NIKKAJI (1)   
Gene (23)   
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