KEGG   DRUG: Granisetron
Entry
D04370                      Drug                                   
Name
Granisetron (JAN/USAN/INN);
Sancuso (TN)
Product
Formula
C18H24N4O
Exact mass
312.195
Mol weight
312.4094
Structure
Simcomp
Class
Gastrointestinal agent
 DG01489  5-HT3-receptor antagonist
 DG01762  Antiemetic
Metabolizing enzyme substrate
 DG01891  CYP1A1 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Same as: C07023
ATC code: A04AA02
Chemical structure group: DG00061
Product (DG00061): D04370<US> D00677<JP/US>
Efficacy
Anti-emetic, Serotonin 5-HT3 receptor antagonist
Target
HTR3B [HSA:9177] [KO:K04819]
  Pathway
hsa04726  Serotonergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP1A1 [HSA:1543]
Interaction
Structure map
map07211  Serotonin receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A04 ANTIEMETICS AND ANTINAUSEANTS
   A04A ANTIEMETICS AND ANTINAUSEANTS
    A04AA Serotonin (5HT3) antagonists
     A04AA02 Granisetron
      D04370  Granisetron (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Emetogenic Therapy Adjuncts
   Granisetron
    D04370  Granisetron (JAN/USAN/INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01489  5-HT3-receptor antagonist
   DG00061  Granisetron
    D04370  Granisetron
  DG01762  Antiemetic
   DG00061  Granisetron
    D04370  Granisetron
 Metabolizing enzyme substrate
  DG01891  CYP1A1 substrate
   DG00061  Granisetron
    D04370  Granisetron
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00061  Granisetron
     D04370  Granisetron
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Serotonin
    HTR3B
     D04370  Granisetron (JAN/USAN/INN) <US>
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D04370
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D04370
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01489  5-HT3-receptor antagonist
   DG00061  Granisetron
  DG01762  Antiemetic
   DG00061  Granisetron
 Metabolizing enzyme substrate
  DG01891  CYP1A1 substrate
   DG00061  Granisetron
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00061  Granisetron
Other DBs
CAS: 109889-09-0
PubChem: 47206270
ChEBI: 5537
LigandBox: D04370
NIKKAJI: J258.427A
KCF data

ATOM        23
            1   C1x C    19.3438  -16.4308
            2   C1x C    19.4619  -15.4691
            3   C1y C    20.5155  -16.1496
            4   C1y C    20.8436  -14.9779
            5   N1y N    19.5782  -13.6656
            6   C1x C    22.3902  -16.1496
            7   C1x C    22.1090  -14.9779
            8   C1y C    23.4213  -16.7120
            9   N1b N    24.4993  -17.6025
            10  C5a C    25.7179  -17.6025
            11  C8y C    26.3272  -16.5245
            12  O5a O    26.3272  -18.7273
            13  C1a C    18.8291  -12.4814
            14  C1x C    18.2878  -14.9430
            15  C8y C    27.7272  -16.5245
            16  C8y C    28.1598  -15.1930
            17  N4y N    27.0272  -14.3701
            18  N5x N    25.8946  -15.1930
            19  C8x C    28.6640  -17.5649
            20  C8x C    30.0334  -17.2738
            21  C8x C    30.4660  -15.9423
            22  C8x C    29.5292  -14.9019
            23  C1a C    27.0273  -12.9500
BOND        26
            1     1   3 1
            2     2   4 1
            3     3   5 1
            4     3   6 1
            5     4   7 1
            6     6   8 1
            7     8   9 1
            8     9  10 1
            9    10  11 1
            10   10  12 2
            11    4   5 1
            12    7   8 1
            13    5  13 1
            14    2  14 1
            15    1  14 1
            16   11  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   11  18 2
            21   15  19 2
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   16  22 2
            26   17  23 1

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