KEGG   DRUG: Guanethidine monosulfate
Entry
D04382                      Drug                                   
Name
Guanethidine monosulfate (USP);
Guanethidine sulfate (JP18);
Ismelin (TN)
Formula
C10H22N4. H2SO4
Exact mass
296.1518
Mol weight
296.387
Structure
Class
Cardiovascular agent
 DG01739  Peripherally-acting antiadrenergic
Neuropsychiatric agent
 DG03085  Selective norepinephrine reuptake inhibitor (NRI)
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
Remark
ATC code: C02CC02 S01EX01
Chemical structure group: DG00258
Efficacy
Antihypertensive, Noradrenaline release inhibitor
Comment
Guanidine derivative
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
  Pathway
hsa04721  Synaptic vesicle cycle
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CC Guanidine derivatives
     C02CC02 Guanethidine
      D04382  Guanethidine monosulfate (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EX Other antiglaucoma preparations
     S01EX01 Guanethidine
      D04382  Guanethidine monosulfate (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01739  Peripherally-acting antiadrenergic
   DG00258  Guanethidine
    D04382  Guanethidine monosulfate
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00258  Guanethidine
    D04382  Guanethidine monosulfate
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00258  Guanethidine
    D04382  Guanethidine monosulfate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D04382  Guanethidine monosulfate (USP)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D04382  Guanethidine sulfate
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01739  Peripherally-acting antiadrenergic
   DG00258  Guanethidine
 Neuropsychiatric agent
  DG03085  Selective norepinephrine reuptake inhibitor (NRI)
   DG00258  Guanethidine
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG00258  Guanethidine
Other DBs
CAS: 645-43-2
PubChem: 47206277
ChEBI: 51016
LigandBox: D04382
NIKKAJI: J237.257F
KCF data

ATOM        19
            1   N1y N    21.4998  -15.4594
            2   C1b C    20.2881  -14.7604
            3   C1x C    21.4998  -16.9041
            4   C1x C    22.5250  -14.4341
            5   C1b C    19.1231  -15.4594
            6   C1x C    22.4784  -17.8828
            7   C1x C    23.9230  -14.4341
            8   N1b N    17.9581  -14.7604
            9   C1x C    23.9230  -17.8828
            10  C1x C    24.9017  -15.4128
            11  C2c C    16.7464  -15.4594
            12  C1x C    24.9017  -16.9041
            13  N1a N    15.5813  -14.7604
            14  N2a N    16.7464  -16.8109
            15  S4a S    30.1701  -16.4848
            16  O1d O    30.1701  -15.0862
            17  O1d O    30.1701  -17.8833
            18  O1d O    31.5686  -16.4848
            19  O1d O    28.7716  -16.4848
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   9 1
            9     7  10 1
            10    8  11 1
            11    9  12 1
            12   11  13 1
            13   11  14 2
            14   10  12 1
            15   15  16 2
            16   15  17 2
            17   15  18 1
            18   15  19 1

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