KEGG   DRUG: Lubiprostone
Entry
D04790                      Drug                                   
Name
Lubiprostone (JAN/USAN/INN);
Amitiza (TN)
Product
AMITIZA (SPECGX LLC), AMITIZA (Takeda Pharmaceuticals America)
  Generic
AMITZA (Direct_Rx), LUBIPROSTONE (Advanced Rx Pharmacy of Tennessee), LUBIPROSTONE (Advanced Rx Pharmacy of Tennessee), LUBIPROSTONE (Amneal Pharmaceuticals LLC), LUBIPROSTONE (AvKARE), LUBIPROSTONE (Dr. Reddy's Laboratories), LUBIPROSTONE (Golden State Medical Supply), LUBIPROSTONE (Natco Pharma USA LLC), LUBIPROSTONE (Par Pharmaceutical), LUBIPROSTONE (Proficient Rx LP), LUBIPROSTONE (Proficient Rx LP), LUBIPROSTONE (Proficient Rx LP), LUBIPROSTONE (Proficient Rx LP), LUBIPROSTONE (Quality Care Products), LUBIPROSTONE (Quality Care Products), LUBIPROSTONE (Sun Pharmaceutical Industries), LUBIPROSTONE (Teva Pharmaceuticals), LUBIPROSTONE (Zydus Lifesciences Limited), LUBIPROSTONE (Zydus Pharmaceuticals USA)
Formula
C20H32F2O5
Exact mass
390.2218
Mol weight
390.4619
Structure
Simcomp
Class
Gastrointestinal agent
 DG01770  Laxative
Remark
Same as: C13707
Therapeutic category: 2359
ATC code: A06AX03
Product: D04790<JP/US>
Efficacy
Peristaltic accelerator, Softener, Clc chloride channel inhibitor
  Disease
Irritable bowel syndrome with constipation [DS:H01615]
Comment
CAS Registry number (136790-76-6) are given for the tautomeric monocyclic isomer
Prostaglandin E1 derivative
Treatment of constipation and bowel preparation
Target
CLCN2 [HSA:1181] [KO:K05011]
  Pathway
hsa04978  Mineral absorption
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A06 DRUGS FOR CONSTIPATION
   A06A DRUGS FOR CONSTIPATION
    A06AX Other drugs for constipation
     A06AX03 Lubiprostone
      D04790  Lubiprostone (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Anti-constipation Agents
   Lubiprostone
    D04790  Lubiprostone (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   235  Purgatives, clysters
    2359  Others
     D04790  Lubiprostone (JAN/USAN/INN)
Drug groups [BR:br08330]
 Gastrointestinal agent
  DG01770  Laxative
   D04790  Lubiprostone
Drug classes [BR:br08332]
 Gastrointestinal agent
  DG01770  Laxative
   D04790  Lubiprostone
Target-based classification of drugs [BR:br08310]
 Ion channels
  Other ion channels
   Chloride channel
    CLCN2
     D04790  Lubiprostone (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04790
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04790
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04790
Other DBs
CAS: 333963-40-9
PubChem: 47206600
ChEBI: 34945
LigandBox: D04790
KCF data

ATOM        27
            1   C1y C    18.4041  -16.3779
            2   C5x C    18.4041  -17.7775
            3   C1x C    19.7352  -18.2099
            4   C1y C    20.5579  -17.0777
            5   C1y C    19.7352  -15.9454
            6   C1b C    17.1921  -15.6781
            7   C1b C    15.9800  -16.3779
            8   O5x O    17.1921  -18.4772
            9   O2x O    21.9575  -17.0777
            10  C1z C    22.6611  -15.8588
            11  C1x C    21.9767  -14.6739
            12  C1x C    20.5737  -14.6741
            13  C1b C    14.7492  -15.6671
            14  C1b C    13.5444  -16.3625
            15  C1b C    12.3624  -15.6799
            16  C1b C    11.1688  -16.3691
            17  C6a C     9.9813  -15.6833
            18  O6a O     8.7905  -16.3708
            19  O6a O     9.9813  -14.2787
            20  O1a O    23.6507  -16.8484
            21  C1d C    23.6507  -14.8692
            22  C1b C    24.8628  -15.5690
            23  C1b C    26.0749  -14.8692
            24  C1b C    27.2870  -15.5690
            25  C1a C    28.4990  -14.8692
            26  X   F    24.6404  -13.8795
            27  X   F    22.6611  -13.8795
BOND        28
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     1   6 1 #Down
            7     6   7 1
            8     2   8 2
            9     4   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12   5 1
            14    7  13 1
            15   13  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 2
            21   10  20 1 #Up
            22   10  21 1 #Down
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   21  26 1
            28   21  27 1

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Disease (1)   
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