KEGG   DRUG: Miglustat
Entry
D05032                      Drug                                   
Name
Miglustat (JAN/USAN/INN);
Brazaves (TN);
Zavesca (TN)
Product
OPFOLDA (AMICUS THERAPEUTICS US), ZAVESCA (Actelion Pharmaceuticals US)
  Generic
MIGLUSTAT (ANI Pharmaceuticals), MIGLUSTAT (CoTherix), YARGESA (Edenbridge Pharmaceuticals LLC.)
Formula
C10H21NO4
Exact mass
219.1471
Mol weight
219.278
Structure
Simcomp
Remark
Therapeutic category: 3999
ATC code: A16AX06
Product: D05032<JP/US>
Efficacy
Lysosomal storage disease treatment, Glucosylceramide synthase inhibitor
  Disease
Type 1 Gaucher disease [DS:H00126]
Pompe disease [DS:H01940]
Target
UGCG [HSA:7357] [KO:K00720]
  Pathway
hsa00600  Sphingolipid metabolism
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AX Various alimentary tract and metabolism products
     A16AX06 Miglustat
      D05032  Miglustat (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Genetic, Enzyme, or Protein Disorder: Replacement, Modifiers, Treatment
  Miglustat
   D05032  Miglustat (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D05032  Miglustat (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Transferases (EC2)
   Hexosyltransferases
    UGCG
     D05032  Miglustat (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05032
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05032
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05032
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05032
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D05032
Other DBs
CAS: 72599-27-0
PubChem: 47206759
ChEBI: 50381
PDB-CCD: NBV[PDBj]
LigandBox: D05032
NIKKAJI: J258.518I
KCF data

ATOM        15
            1   C1y C    33.6700  -19.1800
            2   C1y C    33.6700  -20.5800
            3   C1y C    34.8824  -21.2800
            4   C1y C    36.0949  -20.5800
            5   C1x C    36.0949  -19.1800
            6   N1y N    34.8824  -18.4800
            7   O1a O    37.3260  -21.2910
            8   O1a O    32.4576  -21.2800
            9   O1a O    34.8824  -22.6798
            10  C1b C    32.4576  -18.4800
            11  C1b C    34.8824  -17.0802
            12  C1b C    36.0780  -16.3898
            13  C1b C    37.2652  -17.0752
            14  C1a C    38.4566  -16.3872
            15  O1a O    31.2621  -19.1704
BOND        15
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1 #Down
            8     2   8 1 #Down
            9     3   9 1 #Up
            10    1  10 1 #Up
            11    6  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  15 1

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Ontology (9)   
   KEGG BRITE (9)   
Disease (3)   
   KEGG DISEASE (3)   
Drug (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (21)   

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