KEGG   DRUG: Moricizine
Entry
D05077                      Drug                                   
Name
Moricizine (USAN);
Moracizine (INN)
Formula
C22H25N3O4S
Exact mass
427.1566
Mol weight
427.5166
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
Remark
Same as: C07743
ATC code: C01BG01
Chemical structure group: DG00208
Efficacy
Antiarrhythmic, Cardiac depressant, Sodium channel blocker
Comment
Phenothiazine derivative
Target
SCN5A [HSA:6331] [KO:K04838]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
CYP induction: CYP1A2 [HSA:1544]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG01 Moracizine
      D05077  Moricizine (USAN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG00208  Moracizine
    D05077  Moricizine
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00208  Moracizine
    D05077  Moricizine
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN5A
     D05077  Moricizine (USAN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D05077
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG00208  Moracizine
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00208  Moracizine
Other DBs
CAS: 31883-05-3
PubChem: 47206804
ChEBI: 6997
LigandBox: D05077
NIKKAJI: J19.957E
KCF data

ATOM        30
            1   C8y C    23.2514  -19.4836
            2   N1y N    22.0493  -18.7834
            3   C8y C    23.2514  -20.8840
            4   C8x C    24.4533  -18.7834
            5   C8y C    20.8298  -19.4836
            6   C5a C    22.0435  -17.3889
            7   S2x S    22.0493  -21.5843
            8   C8x C    24.4533  -21.5843
            9   C8y C    25.6671  -19.4836
            10  C8y C    20.8298  -20.8840
            11  C8x C    19.6161  -18.7834
            12  C1b C    23.2572  -16.6887
            13  O5a O    20.8240  -16.6887
            14  C8x C    25.6671  -20.8840
            15  N1b N    26.8808  -18.7776
            16  C8x C    19.6161  -21.5843
            17  C8x C    18.3966  -19.4836
            18  C1b C    23.2572  -15.2942
            19  C7a C    28.0945  -19.4719
            20  C8x C    18.3966  -20.8840
            21  N1y N    24.4709  -14.5880
            22  O7a O    29.3082  -18.7660
            23  O6a O    28.0945  -20.8783
            24  C1x C    25.6729  -15.2882
            25  C1x C    24.5350  -13.1876
            26  C1b C    30.5160  -19.4662
            27  C1x C    26.8867  -14.5823
            28  C1x C    25.6729  -12.4876
            29  C1a C    31.7296  -18.7602
            30  O2x O    26.8867  -13.1818
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    6  13 2
            13    8  14 2
            14    9  15 1
            15   10  16 1
            16   11  17 2
            17   12  18 1
            18   15  19 1
            19   16  20 2
            20   18  21 1
            21   19  22 1
            22   19  23 2
            23   21  24 1
            24   21  25 1
            25   22  26 1
            26   24  27 1
            27   25  28 1
            28   26  29 1
            29   27  30 1
            30    7  10 1
            31    9  14 1
            32   17  20 1
            33   28  30 1

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Ontology (4)   
   KEGG BRITE (4)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (5)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (14)   

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