KEGG   DRUG: Nepafenac
Entry
D05143                      Drug                                   
Name
Nepafenac (JAN/USAN/INN);
Nevanac (TN)
Product
ILEVRO (Novartis Pharmaceuticals Corporation), NEVANAC (Novartis Pharmaceuticals Corporation)
Formula
C15H14N2O2
Exact mass
254.1055
Mol weight
254.2839
Structure
Simcomp
Class
Anti-inflammatory
 DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
  DG01906  Anti-inflammatory drug, acetic acid derivatives
Remark
Therapeutic category: 1319
ATC code: S01BC10
Product: D05143<JP/US>
Efficacy
Analgesic, Anti-inflammatory, COX inhibitor
Target
PTGS1 (COX1) [HSA:5742] [KO:K00509]
PTGS2 (COX2) [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC10 Nepafenac
      D05143  Nepafenac (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Nonsteroidal Anti-Inflammatory Drugs, Ophthalmic
    Nepafenac
     D05143  Nepafenac (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D05143  Nepafenac (JAN/USAN/INN)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   DG01906  Anti-inflammatory drug, acetic acid derivatives
    D05143  Nepafenac
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01504  Nonsteroidal anti-inflammatory drug (NSAID)
   D05143  Nepafenac
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases (EC1)
   Prostaglandin synthase
    PTGS1 (COX1)
     D05143  Nepafenac (JAN/USAN/INN) <JP/US>
    PTGS2 (COX2)
     D05143  Nepafenac (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05143
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05143
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05143
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05143
Other DBs
CAS: 78281-72-8
PubChem: 47206867
ChEBI: 75922
LigandBox: D05143
NIKKAJI: J332.082K
KCF data

ATOM        19
            1   C8x C     6.3700  -15.1200
            2   C8x C     6.3700  -16.5200
            3   C8x C     7.5824  -17.2200
            4   C8x C     8.7949  -16.5200
            5   C8y C     8.7949  -15.1200
            6   C8x C     7.5824  -14.4200
            7   C8x C    11.2197  -16.5200
            8   C8y C    11.2197  -15.1200
            9   C5a C    10.0073  -14.4200
            10  C8x C    12.4322  -17.2200
            11  C8x C    13.6446  -16.5200
            12  C8y C    13.6446  -15.1200
            13  C8y C    12.4322  -14.4200
            14  O5a O    10.0073  -13.0200
            15  C1b C    14.8611  -14.4177
            16  N1a N    12.4322  -13.0203
            17  C5a C    16.0586  -15.1092
            18  N1a N    17.2449  -14.4243
            19  O5a O    16.0587  -16.5197
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    9  14 2
            16   12  15 1
            17   13  16 1
            18   15  17 1
            19   17  18 1
            20   17  19 2

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Ontology (10)   
   KEGG BRITE (10)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (4)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
Gene (4)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (2)   
All databases (21)   

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