| Entry |
|
|---|
| Name |
Paliperidone palmitate (JAN/USAN);
Xeplion (TN);
Trevicta (TN);
Invega sustenna (TN);
Invega trinza (TN) |
|---|
| Product |
|
|---|
| Formula |
C39H57FN4O4
|
|---|
| Exact mass |
664.4364
|
|---|
| Mol weight |
664.8927
|
|---|
| Structure |
|
|---|
| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03005 Serotonin-dopamine antagonist (SDA)
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
|
|---|
| Remark |
| Therapeutic category: | 1179 |
| Product (DG00907): | D05339<JP/US> D05340<JP/US> |
|
|---|
| Efficacy |
Antipsychotic, Serotonin receptor antagonist, Dopamine D2 receptor antagonist |
|---|
| Disease |
|
|---|
| Comment |
Serotonin-dopamine antagonists (SDA)
Risperidone derivative
Treatment of schizophrenia
Active form of prodrug: Paliperidone [DR: D05339]
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AX Other antipsychotics
N05AX13 Paliperidone
D05340 Paliperidone palmitate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
Antipsychotics
2nd Generation/Atypical
Paliperidone
D05340 Paliperidone palmitate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D05340 Paliperidone palmitate (JAN/USAN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00907 Paliperidone
D05340 Paliperidone palmitate
DG03005 Serotonin-dopamine antagonist (SDA)
DG00907 Paliperidone
D05340 Paliperidone palmitate
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
DG00907 Paliperidone
D05340 Paliperidone palmitate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D05340 Paliperidone palmitate (JAN/USAN) <JP/US>
Serotonin
HTR2A
D05340 Paliperidone palmitate (JAN/USAN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D05340
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D05340
Prodrugs [br08324.html]
D05340
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00907 Paliperidone
DG03005 Serotonin-dopamine antagonist (SDA)
DG00907 Paliperidone
DG03200 Antipsychotic agent
DG03064 Atypical antipsychotic
DG00907 Paliperidone
Prodrugs [br08324.html]
DG00907
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 48
1 C8y C 20.0900 -20.2300
2 C8y C 20.0900 -18.8300
3 N5x N 21.2800 -18.1300
4 C8y C 22.5400 -18.8300
5 N4y N 22.5400 -20.2300
6 C8y C 21.2800 -20.9300
7 C1y C 23.7300 -18.1300
8 C1x C 24.9200 -18.8300
9 C1x C 24.9200 -20.2300
10 C1x C 23.7300 -20.9300
11 O7a O 23.7300 -16.7300
12 C1a C 18.9000 -18.1300
13 O5x O 21.2800 -22.3300
14 C1b C 18.9000 -20.9300
15 C1b C 17.7100 -20.2300
16 N1y N 16.5200 -20.9300
17 C1x C 16.5200 -22.3300
18 C1x C 15.3300 -23.0300
19 C1y C 14.1400 -22.3300
20 C1x C 14.1400 -20.9300
21 C1x C 15.3300 -20.2300
22 C8y C 12.8100 -23.0300
23 N5x N 11.6900 -22.1900
24 O2x O 10.5700 -23.0300
25 C8y C 10.9900 -24.3600
26 C8y C 12.3900 -24.3600
27 C8x C 10.2900 -25.5500
28 C8y C 10.9900 -26.8100
29 C8x C 12.3900 -26.8100
30 C8x C 13.0900 -25.5500
31 X F 10.2900 -28.0000
32 C7a C 22.5176 -16.0300
33 C1b C 21.3221 -16.7204
34 O6a O 22.5175 -14.6302
35 C1b C 20.1347 -16.0349
36 C1b C 18.9435 -16.7229
37 C1b C 17.7540 -16.0362
38 C1b C 16.5639 -16.7235
39 C1b C 15.3738 -16.0365
40 C1b C 14.1840 -16.7237
41 C1b C 12.9938 -16.0366
42 C1b C 11.8040 -16.7238
43 C1b C 10.6138 -16.0366
44 C1b C 9.4240 -16.7238
45 C1b C 8.2338 -16.0366
46 C1b C 7.0440 -16.7238
47 C1b C 5.8538 -16.0366
48 C1a C 4.6640 -16.7238
BOND 52
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 7 11 1 #Down
13 2 12 1
14 6 13 2
15 1 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 16 21 1
24 19 22 1
25 22 23 2
26 23 24 1
27 24 25 1
28 25 26 1
29 22 26 1
30 25 27 2
31 27 28 1
32 28 29 2
33 29 30 1
34 26 30 2
35 28 31 1
36 11 32 1
37 32 33 1
38 32 34 2
39 33 35 1
40 35 36 1
41 36 37 1
42 37 38 1
43 38 39 1
44 39 40 1
45 40 41 1
46 41 42 1
47 42 43 1
48 43 44 1
49 44 45 1
50 45 46 1
51 46 47 1
52 47 48 1
|
|---|
