KEGG   DRUG: Pazopanib hydrochloride
Entry
D05380                      Drug                                   
Name
Pazopanib hydrochloride (JAN/USAN);
Votrient (TN)
Product
VOTRIENT (Novartis Pharmaceuticals Corporation)
  Generic
PAZOPANIB (Apotex Corp.), PAZOPANIB (Golden State Medical Supply), PAZOPANIB (SUN PHARMACEUTICAL INDUSTRIES), PAZOPANIB (Teva Pharmaceuticals)
Formula
C21H23N7O2S. HCl
Exact mass
473.1401
Mol weight
473.979
Structure
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Therapeutic category: 4291
ATC code: L01EX03
Product: D05380<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
  Disease
Renal cell carcinoma [DS:H00021]
Soft tissue sarcoma [DS:H02427]
Target
PDGFR [HSA:5156 5159] [KO:K04363 K05089]
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa05200  Pathways in cancer
Interaction
Structure map
map07045  Antineoplastics - protein kinase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01E PROTEIN KINASE INHIBITORS
    L01EX Other protein kinase inhibitors
     L01EX03 Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Pazopanib
    D05380  Pazopanib hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D05380  Pazopanib hydrochloride (JAN/USAN)
Drug groups [BR:br08330]
 Antineoplastic
  DG01918  Tyrosine kinase inhibitor
   DG01917  Receptor tyrosine kinase inhibitor
    D05380  Pazopanib hydrochloride
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFR
     D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
    KIT (CD117)
     D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
   VEGFR family
    VEGFR1 (FLT1)
     D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
    VEGFR2 (KDR)
     D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
    VEGFR3 (FLT4)
     D05380  Pazopanib hydrochloride (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D05380
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D05380
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05380
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D05380
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D05380
Other DBs
CAS: 635702-64-6
PubChem: 47207056
ChEBI: 71217
LigandBox: D05380
KCF data

ATOM        32
            1   C8x C     8.1900  -18.2000
            2   C8y C     8.1900  -19.6000
            3   C8y C     9.4024  -20.3000
            4   C8x C    10.6149  -19.6000
            5   C8y C    10.6149  -18.2000
            6   C8x C     9.4024  -17.5000
            7   N5x N    13.0397  -19.6000
            8   C8y C    13.0397  -18.2000
            9   N1b N    11.8273  -17.5000
            10  C8x C    14.2522  -20.3000
            11  C8x C    15.4646  -19.6000
            12  C8y C    15.4646  -18.2000
            13  N5x N    14.2522  -17.5000
            14  N1c N    16.6811  -17.4977
            15  C8y C    17.8786  -18.1892
            16  C1a C    16.6811  -16.1002
            17  C1a C     6.9776  -20.3000
            18  S4a S     9.4024  -21.6998
            19  N1a N     9.4024  -23.0998
            20  O3c O     7.9800  -21.6998
            21  O3c O    10.7800  -21.6998
            22  C8x C    17.8787  -19.5997
            23  C8x C    19.0911  -20.2996
            24  C8y C    20.3035  -19.5996
            25  C8y C    20.3035  -18.1891
            26  C8x C    19.0910  -17.4892
            27  C8y C    21.6450  -20.0354
            28  N4y N    22.4741  -18.8942
            29  N5x N    21.6449  -17.7532
            30  C1a C    23.8700  -18.8942
            31  C1a C    22.0716  -21.3485
            32  X   Cl   22.1900  -23.9400
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15   12  14 1
            16   14  15 1
            17   14  16 1
            18    2  17 1
            19    3  18 1
            20   18  19 1
            21   18  20 2
            22   18  21 2
            23   15  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   15  26 2
            29   24  27 2
            30   27  28 1
            31   28  29 1
            32   25  29 2
            33   28  30 1
            34   27  31 1

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Ontology (10)   
   KEGG BRITE (10)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (12)   
   KEGG ORTHOLOGY (6)   
   KEGG GENES (6)   
All databases (29)   

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