| Entry |
|
|---|
| Name |
Practolol (USAN) |
|---|
| Formula |
C14H22N2O3
|
|---|
| Exact mass |
266.163
|
|---|
| Mol weight |
266.3361
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
|
|---|
| Remark |
|
|---|
| Efficacy |
Antiarrhythmic, beta1-Adrenergic receptor antagonist |
|---|
| Comment |
Propranolol derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C07 BETA BLOCKING AGENTS
C07A BETA BLOCKING AGENTS
C07AB Beta blocking agents, selective
C07AB01 Practolol
D05587 Practolol (USAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01464 beta-Adrenergic receptor antagonist (Beta blocker)
DG01461 beta1-Adrenergic receptor antagonist
D05587 Practolol
DG01653 Antiarrhythmics
DG01806 Class II antiarrhythmic agent
D05587 Practolol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB1
D05587 Practolol (USAN)
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C8y C 16.1700 -14.8400
2 C8x C 14.9800 -15.5400
3 C8x C 17.4300 -15.5400
4 O2a O 16.1700 -13.4400
5 C8x C 14.9800 -16.9400
6 C8x C 17.4300 -16.9400
7 C1b C 17.3600 -12.7400
8 C8y C 16.2400 -17.6400
9 C1c C 18.6200 -13.3700
10 N1b N 16.2400 -19.0400
11 C1b C 19.8100 -12.6700
12 O1a O 18.6200 -14.7700
13 C5a C 15.0500 -19.7400
14 N1b N 21.0000 -13.3700
15 C1a C 13.8600 -19.0400
16 O5a O 15.0500 -21.1400
17 C1c C 22.1900 -12.6700
18 C1a C 23.4500 -13.3000
19 C1a C 22.1900 -11.2700
BOND 19
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 3 6 1
6 4 7 1
7 5 8 1
8 7 9 1
9 8 10 1
10 9 11 1
11 9 12 1
12 10 13 1
13 11 14 1
14 13 15 1
15 13 16 2
16 14 17 1
17 17 18 1
18 17 19 1
19 6 8 2
|
|---|
