KEGG   DRUG: Tocainide
Entry
D06172                      Drug                                   
Name
Tocainide (USAN/INN)
Formula
C11H16N2O
Exact mass
192.1263
Mol weight
192.2575
Structure
Simcomp
Class
Cardiovascular agent
 DG01653  Antiarrhythmics
  DG01652  Class I antiarrhythmic agent
   DG01651  Class Ib antiarrhythmic agent
Remark
Same as: C07142
ATC code: C01BB03
Chemical structure group: DG00198
Efficacy
Antiarrhythmic, Sodium channel blocker
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07231  Sodium channel blocking drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BB Antiarrhythmics, class Ib
     C01BB03 Tocainide
      D06172  Tocainide (USAN/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00198  Tocainide
      D06172  Tocainide
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D06172  Tocainide (USAN/INN)
    SCN2A
     D06172  Tocainide (USAN/INN)
    SCN3A
     D06172  Tocainide (USAN/INN)
    SCN4A
     D06172  Tocainide (USAN/INN)
    SCN5A
     D06172  Tocainide (USAN/INN)
    SCN8A
     D06172  Tocainide (USAN/INN)
    SCN9A
     D06172  Tocainide (USAN/INN)
    SCN10A
     D06172  Tocainide (USAN/INN)
    SCN11A
     D06172  Tocainide (USAN/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   DG01652  Class I antiarrhythmic agent
    DG01651  Class Ib antiarrhythmic agent
     DG00198  Tocainide
Other DBs
CAS: 41708-72-9
PubChem: 47207830
ChEBI: 9611
LigandBox: D06172
NIKKAJI: J16.873D
KCF data

ATOM        14
            1   C8y C    26.1204  -17.9085
            2   N1b N    24.9090  -17.2156
            3   C8y C    26.1145  -19.3179
            4   C8y C    27.3317  -17.2213
            5   C5a C    23.6978  -17.9028
            6   C8x C    27.3317  -20.0226
            7   C1a C    24.8974  -20.0167
            8   C8x C    28.5372  -17.9144
            9   C1a C    27.2676  -15.8121
            10  C1c C    22.4863  -17.2039
            11  O5a O    23.7618  -19.3005
            12  C8x C    28.5431  -19.3179
            13  C1a C    21.2751  -17.8969
            14  N1a N    22.4863  -15.8005
BOND        14
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     3   6 2
            6     3   7 1
            7     4   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12   10  13 1
            13   10  14 1
            14    8  12 2

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (5)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   NIKKAJI (1)   
Gene (18)   
   KEGG ORTHOLOGY (9)   
   KEGG GENES (9)   
All databases (30)   

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