KEGG   DRUG: Varenicline tartrate
Entry
D06282                      Drug                                   
Name
Varenicline tartrate (JAN/USAN);
Chantix (TN);
Champix (TN);
Tyrvaya (TN)
Product
CHANTIX (Aphena Pharma Solutions - Tennessee), CHANTIX (Pfizer Laboratories Div Pfizer), CHANTIX (Proficient Rx LP), CHANTIX (Proficient Rx LP), TYRVAYA (Oyster Point Pharma)
  Generic
VARENICLINE (A-S Medication Solutions), VARENICLINE (A-S Medication Solutions), VARENICLINE (American Health Packaging), VARENICLINE (Apotex Corp), VARENICLINE (Ascend Laboratories), VARENICLINE (AvKARE), VARENICLINE (Bryant Ranch Prepack), VARENICLINE (Bryant Ranch Prepack), VARENICLINE (Camber Pharmaceuticals), VARENICLINE (Golden State Medical Supply), VARENICLINE (Major Pharmaceuticals), VARENICLINE (Mylan Pharmaceuticals), VARENICLINE (Par Pharmaceutical), VARENICLINE (Zydus Lifesciences Limited), VARENICLINE (Zydus Pharmaceuticals USA), VARENICLINE TARTRATE (Glenmark Pharmaceuticals), VARENICLINE TARTRATE (Leading Pharma), VARENICLINE TARTRATE (Lupin Pharmaceuticals)
Formula
C13H13N3. C4H6O6
Exact mass
361.1274
Mol weight
361.3493
Structure
Class
Neuropsychiatric agent
 DG01571  Nicotinic cholinergic receptor partial agonist
Remark
Therapeutic category: 7990
ATC code: N07BA03 S01XA28
Chemical structure group: DG00995
Product (DG00995): D06282<JP/US>
Efficacy
Smoking cessation adjunct, Selective nicotinic acetylcholine receptor modulator
  Disease
Dry eye disease [DS:H01641]
Target
CHRNA4/CHRNB2 [HSA:1137 1141] [KO:K04806 K04813]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BA Drugs used in nicotine dependence
     N07BA03 Varenicline
      D06282  Varenicline tartrate (JAN/USAN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01X OTHER OPHTHALMOLOGICALS
    S01XA Other ophthalmologicals
     S01XA28 Varenicline
      D06282  Varenicline tartrate (JAN/USAN) <JP/US>
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Smoking Cessation Agents
   Varenicline
    D06282  Varenicline tartrate (JAN/USAN)
 Ophthalmic Agents
  Ophthalmic Agents, Other
   Varenicline
    D06282  Varenicline tartrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 7  Agents not mainly for therapeutic purpose
  79  Other agents not mainly for therapeutic purpose
   799  Miscellaneous
    7990  Miscellaneous
     D06282  Varenicline tartrate (JAN/USAN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01571  Nicotinic cholinergic receptor partial agonist
   DG00995  Varenicline
    D06282  Varenicline tartrate
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   Acetylcholine (nicotinic)
    CHRNA4/CHRNB2
     D06282  Varenicline tartrate (JAN/USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06282
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06282
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06282
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06282
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01571  Nicotinic cholinergic receptor partial agonist
   DG00995  Varenicline
Other DBs
CAS: 375815-87-5
PubChem: 47207939
ChEBI: 84507
LigandBox: D06282
KCF data

ATOM        26
            1   C8y C     5.3200   -5.3900
            2   C1y C     4.2000   -4.4800
            3   C1x C     2.8700   -4.8300
            4   N1x N     2.2400   -6.0900
            5   C8y C     5.3200   -6.7900
            6   C1x C     2.8700   -7.3500
            7   C1y C     4.2000   -7.6300
            8   C8x C     6.5324   -7.4900
            9   C8y C     7.7449   -6.7900
            10  C8y C     7.7449   -5.3900
            11  C8x C     6.5324   -4.6900
            12  N5x N     8.9573   -7.4900
            13  C8x C    10.1697   -6.7900
            14  C8x C    10.1697   -5.3900
            15  N5x N     8.9573   -4.6900
            16  C1x C     3.5547   -6.0585
            17  O6a O    12.2731   -5.6706
            18  C6a C    13.4856   -6.3706
            19  C1c C    14.6981   -5.6706
            20  C1c C    15.9105   -6.3706
            21  C6a C    17.1231   -5.6706
            22  O6a O    18.3355   -6.3706
            23  O6a O    13.4856   -7.7705
            24  O1a O    14.6981   -4.2705
            25  O1a O    15.9105   -7.7706
            26  O6a O    17.1231   -4.2708
BOND        28
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     5   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    1  11 2
            13    9  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18    2  16 1
            19    7  16 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   18  23 2
            26   19  24 1 #Down
            27   20  25 1 #Down
            28   21  26 2

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   KEGG BRITE (9)   
Disease (1)   
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Drug (3)   
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   SIDER (1)   
Chemical substance (2)   
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Gene (4)   
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