| Entry |
|
|---|
| Name |
Fluticasone furoate (JAN/USAN/INN);
Veramyst (TN) |
|---|
| Product |
|
|---|
| Formula |
C27H29F3O6S
|
|---|
| Exact mass |
538.1637
|
|---|
| Mol weight |
538.5758
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00420): | D01708<JP/US> D06315<JP/US> |
| Product (mixture): | D10501<JP/US> D11035<JP/US> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC17 Fluticasone
D06315 Fluticasone furoate (JAN/USAN/INN) <JP/US>
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AD Corticosteroids
R01AD08 Fluticasone
D06315 Fluticasone furoate (JAN/USAN/INN) <JP/US>
R01AD12 Fluticasone furoate
D06315 Fluticasone furoate (JAN/USAN/INN) <JP/US>
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03B OTHER DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES, INHALANTS
R03BA Glucocorticoids
R03BA05 Fluticasone
D06315 Fluticasone furoate (JAN/USAN/INN) <JP/US>
R03BA09 Fluticasone furoate
D06315 Fluticasone furoate (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Anti-inflammatories, Inhaled Corticosteroids
Fluticasone
D06315 Fluticasone furoate (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
132 Otic and nasal agents
1329 Others
D06315 Fluticasone furoate (JAN/USAN/INN)
2 Agents affecting individual organs
22 Respiratory organ agents
229 Miscellaneous
2290 Miscellaneous
D06315 Fluticasone furoate (JAN/USAN/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00420 Fluticasone
D06315 Fluticasone furoate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00420 Fluticasone
D06315 Fluticasone furoate
Drug classes [BR:br08332]
Anti-inflammatory
DG01955 Corticosteroid
D06315 Fluticasone furoate
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D06315 Fluticasone furoate (JAN/USAN/INN) <JP/US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D06315
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D06315
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D06315
Rx-to-OTC switch list in the USA [br08315.html]
D06315
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00420 Fluticasone
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00420 Fluticasone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 37
1 C2x C 19.6000 -28.4200
2 C5x C 19.6000 -29.7500
3 C2x C 20.7900 -30.4500
4 C2y C 21.9100 -29.7500
5 C1z C 21.9100 -28.4200
6 C2x C 20.7900 -27.7200
7 C1y C 23.1000 -30.4500
8 C1x C 24.3600 -29.7500
9 C1y C 24.3600 -28.4200
10 C1z C 23.1000 -27.7200
11 C1y C 25.4100 -27.7200
12 C1z C 25.4100 -26.3900
13 C1x C 24.3600 -25.6900
14 C1y C 23.1000 -26.3900
15 C1x C 27.7200 -27.7200
16 C1y C 27.7200 -26.3900
17 C1z C 26.5300 -25.6900
18 O5x O 18.4100 -30.4500
19 C1a C 21.9100 -27.0200
20 X F 23.1000 -29.0500
21 O1a O 21.9100 -25.6900
22 C1a C 25.4100 -24.9900
23 O7a O 27.9300 -24.7800
24 C1a C 29.1200 -26.3900
25 X F 23.1000 -31.8500
26 C5a C 26.5300 -24.2900
27 O5a O 27.7900 -23.5900
28 S2a S 25.2700 -23.5900
29 C1b C 24.0800 -24.2900
30 X F 22.8900 -23.5900
31 C7a C 29.1200 -24.0800
32 C8y C 30.3100 -24.7800
33 O6a O 29.1200 -22.6800
34 C8x C 30.8000 -26.1100
35 C8x C 32.2000 -26.1100
36 C8x C 32.6200 -24.7800
37 O2x O 31.4300 -23.9400
BOND 41
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 10 20 1 #Down
24 14 21 1 #Up
25 12 22 1 #Up
26 17 23 1 #Down
27 16 24 1 #Down
28 7 25 1 #Down
29 17 26 1 #Up
30 26 27 2
31 26 28 1
32 28 29 1
33 29 30 1
34 31 32 1
35 31 23 1
36 31 33 2
37 32 34 2
38 34 35 1
39 35 36 2
40 36 37 1
41 32 37 1
|
|---|
