KEGG   DRUG: Romidepsin
Entry
D06637                      Drug                                   
Name
Romidepsin (JAN/USAN/INN);
Istodax (TN)
Product
ISTODAX (Celgene Corporation), ROMIDEPSIN (Teva Parenteral Medicines)
  Generic
ROMIDEPSIN (Fresenius Kabi USA)
Formula
C24H36N4O6S2
Exact mass
540.2076
Mol weight
540.6958
Structure
Class
Antineoplastic
 DG03133  Histone deacetylase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
Remark
Therapeutic category: 4291
ATC code: L01XH02
Product: D06637<JP/US>
Efficacy
Antineoplastic, Histone deacetylase inhibitor
  Disease
Peripheral T-cell lymphoma [DS:H01892]
Cutaneous T-Cell Lymphoma [DS:H01463]
Target
HDAC [HSA:3065 3066 8841 9759 10014 10013 51564 55869 9734 83933 79885] [KO:K06067 K11404 K11406 K11407 K11408 K11405 K11409 K18671 K11418]
  Pathway
hsa04110  Cell cycle
hsa04330  Notch signaling pathway
hsa05200  Pathways in cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XH Histone deacetylase (HDAC) inhibitors
     L01XH02 Romidepsin
      D06637  Romidepsin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Romidepsin
    D06637  Romidepsin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06637  Romidepsin (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antineoplastic
  DG03133  Histone deacetylase inhibitor
   D06637  Romidepsin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   D06637  Romidepsin
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases (EC3)
   Histone deacetylase
    HDAC
     D06637  Romidepsin (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06637
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06637
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06637
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D06637
Other DBs
CAS: 128517-07-7
PubChem: 47208288
ChEBI: 61080
LigandBox: D06637
NIKKAJI: J575.851C
KCF data

ATOM        36
            1   S3x S    18.9000  -16.8000
            2   S3x S    18.9000  -18.2000
            3   C1x C    20.6724  -18.9000
            4   C1x C    22.5149  -18.2000
            5   C2x C    22.5149  -16.8000
            6   N1x N    18.9000  -14.0000
            7   C1y C    17.6876  -14.7000
            8   C1x C    17.6876  -16.1000
            9   C2x C    23.7273  -16.1000
            10  C5x C    18.9000  -12.6000
            11  C1y C    20.1124  -11.9000
            12  O5x O    17.6876  -11.9000
            13  N1x N    21.5124  -11.9000
            14  C1c C    20.1124  -10.5000
            15  C1a C    21.3079   -9.8096
            16  C1a C    18.8833   -9.7902
            17  C5x C    22.5373  -12.6700
            18  O5x O    23.7518  -11.9688
            19  C1x C    22.5373  -14.0700
            20  C1y C    23.7518  -14.7712
            21  C5x C    16.2876  -14.7000
            22  N1x N    16.2876  -21.3500
            23  O5x O    15.3090  -13.7212
            24  O7x O    25.5018  -14.7712
            25  C2y C    18.0767  -22.0598
            26  C5x C    19.8407  -21.3646
            27  C2b C    18.0766  -23.4499
            28  C1a C    16.8517  -24.1571
            29  N1x N    21.5838  -22.0477
            30  O5x O    19.8411  -19.9503
            31  C1y C    23.3373  -21.3584
            32  C7x C    25.5056  -22.0445
            33  C1c C    23.3374  -19.9503
            34  C1a C    24.5293  -19.2620
            35  C1a C    22.1045  -19.2382
            36  O6a O    26.3265  -23.1651
BOND        37
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     6   7 1
            6     7   8 1
            7     1   8 1
            8     5   9 2
            9     6  10 1
            10   10  11 1
            11   10  12 2
            12   11  13 1
            13   11  14 1 #Up
            14   14  15 1
            15   14  16 1
            16   17  18 2
            17   13  17 1
            18   17  19 1
            19   19  20 1
            20   20   9 1
            21    7  21 1
            22   21  22 1
            23   21  23 2
            24   20  24 1
            25   22  25 1
            26   25  26 1
            27   25  27 2
            28   27  28 1
            29   26  29 1
            30   26  30 2
            31   29  31 1
            32   31  32 1
            33   31  33 1 #Up
            34   33  34 1
            35   33  35 1
            36   24  32 1
            37   32  36 2

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   KEGG BRITE (9)   
Disease (2)   
   KEGG DISEASE (2)   
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   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
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   NIKKAJI (1)   
Gene (20)   
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   KEGG GENES (11)   
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