KEGG   DRUG: Maraviroc
Entry
D06670                      Drug                                   
Name
Maraviroc (JAN/INN);
Selzentry (TN)
  Abbr
MVC
Product
SELZENTRY (A-S Medication Solutions), SELZENTRY (ViiV Healthcare Company)
  Generic
MARAVIROC (Camber Pharmaceuticals), MARAVIROC (XLCare Pharmaceuticals), MARAVIROC (i3 Pharmaceuticals)
Formula
C29H41F2N5O
Exact mass
513.3279
Mol weight
513.6655
Structure
Class
Antiviral
 DG03107  Anti-HIV agent
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 6250
ATC code: J05AX09
Product: D06670<JP/US>
Efficacy
Antiviral, CCR5 antagonist
  Disease
HIV-1 infection (CCR5-tropic) [DS:H01563]
Target
CCR5 (CD195) [HSA:1234] [KO:K04180]
  Pathway
hsa03250  Viral life cycle - HIV-1
hsa04060  Cytokine-cytokine receptor interaction
hsa04061  Viral protein interaction with cytokine and cytokine receptor
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa05170  Human immunodeficiency virus 1 infection
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Structure map
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AX Other antivirals
     J05AX09 Maraviroc
      D06670  Maraviroc (JAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Other
   Maraviroc
    D06670  Maraviroc (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D06670  Maraviroc (JAN/INN)
Drug groups [BR:br08330]
 Antiviral
  DG03107  Anti-HIV agent
   D06670  Maraviroc
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D06670  Maraviroc
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D06670  Maraviroc
Target-based classification of drugs [BR:br08310]
 Cytokines and receptors
  Cytokine receptors
   Chemokine receptors
    CCR5 (CD195)
     D06670  Maraviroc (JAN/INN) <JP/US>
Antimicrobials [BR:br08307]
 Antivirals
  Entry, fusion or uncoating inhibitor
   CCR5 antagonist
    D06670  Maraviroc (JAN/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Entry, fusion or uncoating inhibitor
   CCR5 antagonist
    D06670  Maraviroc (JAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D06670
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06670
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06670
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06670
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D06670
Pharmacogenomic biomarkers [br08341.html]
 Pathogen genome variants in infectious disease treatments
  D06670
Other DBs
CAS: 376348-65-1
PubChem: 47208321
ChEBI: 63608
LigandBox: D06670
KCF data

ATOM        37
            1   C1x C    38.1872  -40.8344
            2   C1x C    38.5234  -39.6913
            3   C1y C    39.3302  -40.5655
            4   C1y C    39.6664  -39.4224
            5   N1y N    38.4561  -38.1448
            6   C1x C    41.1456  -40.5655
            7   C1x C    40.8766  -39.4224
            8   C1y C    42.1541  -41.1034
            9   C1b C    37.2458  -37.4724
            10  C1b C    36.0356  -38.1448
            11  N4y N    43.4322  -41.6434
            12  C8y C    43.8496  -40.3900
            13  N5x N    45.1958  -40.4091
            14  N5x N    45.5837  -41.7142
            15  C8y C    44.4584  -42.4503
            16  C1c C    44.4393  -43.7966
            17  C1a C    45.6040  -44.5453
            18  C1a C    43.2512  -44.4616
            19  C1a C    43.0462  -39.2603
            20  C1c C    34.8710  -37.4724
            21  N1b N    33.7064  -38.1448
            22  C5a C    32.5418  -37.4724
            23  C1y C    31.3772  -38.1448
            24  C8y C    34.8710  -36.1280
            25  C8x C    36.0516  -35.4461
            26  C8x C    36.0514  -34.1013
            27  C8x C    34.8869  -33.4290
            28  C8x C    33.7062  -34.1109
            29  C8x C    33.7064  -35.4556
            30  C1x C    30.2268  -37.4806
            31  C1x C    29.0623  -38.1530
            32  C1z C    29.0622  -39.4977
            33  C1x C    30.2123  -40.1619
            34  C1x C    31.3771  -39.4896
            35  O5a O    32.5418  -36.1278
            36  X   F    27.8867  -40.1764
            37  X   F    27.8796  -38.8148
BOND        41
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     3   6 1
            6     4   7 1
            7     6   8 1
            8     4   5 1
            9     7   8 1
            10    9  10 1
            11    5   9 1
            12    8  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   11  15 1
            18   15  16 1
            19   16  17 1
            20   16  18 1
            21   12  19 1
            22   10  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   20  24 1 #Up
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   28  29 1
            32   24  29 2
            33   23  30 1
            34   30  31 1
            35   31  32 1
            36   32  33 1
            37   33  34 1
            38   23  34 1
            39   22  35 2
            40   32  36 1
            41   32  37 1

» Japanese version   » Back

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Ontology (14)   
   KEGG BRITE (14)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (4)   
   KEGG DGROUP (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (2)   
   PubChem (1)   
   ChEBI (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (24)   

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