KEGG   DRUG: Elvitegravir
Entry
D06677                      Drug                                   
Name
Elvitegravir (JAN/USAN);
Vitekta (TN)
  Abbr
EVG
Formula
C23H23ClFNO5
Exact mass
447.1249
Mol weight
447.8838
Structure
Class
Antiviral
 DG03107  Anti-HIV agent
  DG03135  HIV integrase inhibitor
Remark
ATC code: J05AJ02
Product (mixture): D10755<JP/US> D10756<US>
Efficacy
Antiviral, HIV integrase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Comment
Component of Stribild (TN)
Target
HIV-1 integrase [KO:K24803]
  Pathway
ko03230  Viral genome structure
ko03240  Viral replication
ko03250  Viral life cycle - HIV-1
Interaction
Structure map
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AJ Integrase inhibitors
     J05AJ02 Elvitegravir
      D06677  Elvitegravir (JAN/USAN)
Drug groups [BR:br08330]
 Antiviral
  DG03107  Anti-HIV agent
   DG03135  HIV integrase inhibitor
    D06677  Elvitegravir
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HIV integrase inhibitor
    D06677  Elvitegravir (JAN/USAN)
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   HIV integrase inhibitor
    D06677  Elvitegravir (JAN/USAN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06677
Other DBs
CAS: 697761-98-1
PubChem: 47208328
ChEBI: 72289
PDB-CCD: ELV[PDBj]
LigandBox: D06677
NIKKAJI: J2.543.801I
KCF data

ATOM        31
            1   C8x C    13.1680  -16.5337
            2   C8y C    13.1680  -17.9349
            3   C8y C    14.3815  -18.6355
            4   C8y C    15.5951  -17.9349
            5   C8x C    15.5951  -16.5337
            6   C8x C    14.3815  -15.8330
            7   C1b C    16.8337  -18.6355
            8   C8y C    18.0473  -17.9349
            9   C8x C    19.2608  -18.6355
            10  C8y C    20.4743  -17.9349
            11  C8y C    21.6878  -18.6355
            12  C8y C    22.9013  -17.9349
            13  C6a C    24.1148  -18.6355
            14  O6a O    25.3284  -17.9349
            15  C8y C    20.4743  -16.5337
            16  C8x C    19.2608  -15.8330
            17  C8y C    18.0473  -16.5337
            18  C8x C    22.9013  -16.5337
            19  N4y N    21.6878  -15.8330
            20  C1c C    21.6878  -14.4321
            21  C1c C    22.9221  -13.7192
            22  C1a C    24.1293  -14.4159
            23  C1a C    22.9218  -12.3300
            24  C1b C    20.4952  -13.7434
            25  O1a O    19.3090  -14.4282
            26  O5x O    21.6878  -20.0365
            27  X   F    14.3815  -20.0366
            28  X   Cl   11.9546  -18.6355
            29  O2a O    16.8527  -15.8438
            30  C1a C    16.8680  -14.4319
            31  O6a O    24.1148  -20.0367
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  15 2
            16   15  16 1
            17   16  17 2
            18    8  17 1
            19   12  18 2
            20   18  19 1
            21   15  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   21  23 1
            26   20  24 1 #Down
            27   24  25 1
            28   11  26 2
            29    3  27 1
            30    2  28 1
            31   17  29 1
            32   29  30 1
            33   13  31 2

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (4)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (1)   
   KEGG ORTHOLOGY (1)   
All databases (14)   

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