KEGG   DRUG: Carglumic acid
Entry
D07130                      Drug                                   
Name
Carglumic acid (JAN/USAN/INN);
Carbaglu (TN)
Product
CARBAGLU (Recordati Rare Diseases)
  Generic
CARGLUMIC ACID (Burel Pharmaceuticals), CARGLUMIC ACID (Eton Pharmaceuticals), CARGLUMIC ACID (Navinta LLC)
Formula
C6H10N2O5
Exact mass
190.059
Mol weight
190.154
Structure
Simcomp
Remark
Same as: C05829
Therapeutic category: 3999
ATC code: A16AA05
Product: D07130<JP/US>
Efficacy
Antihyperammonemic
  Disease
NAGS deficiency [DS:H01032]
Comment
Treatment of hyperammonaemia due to N-acetylglutamate synthase (NAGS) deficiency
Target
CPS1 [HSA:1373] [KO:K01948]
  Pathway
hsa00220  Arginine biosynthesis
hsa00250  Alanine, aspartate and glutamate metabolism
hsa00910  Nitrogen metabolism
  Network
nt06010  Urea cycle
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A16 OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
   A16A OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
    A16AA Amino acids and derivatives
     A16AA05 Carglumic acid
      D07130  Carglumic acid (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Electrolytes/Minerals/Metals/Vitamins
  Electrolyte/Mineral Replacement
   Carglumic  Acid
    D07130  Carglumic acid (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D07130  Carglumic acid (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Ligases (EC6)
   Carbamoyl-phosphate synthase
    CPS1
     D07130  Carglumic acid (JAN/USAN/INN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D07130
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D07130
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D07130
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D07130
Pharmacogenomic biomarkers [br08341.html]
 Germline mutations in genetic disorder treatments
  D07130
Other DBs
CAS: 1188-38-1
PubChem: 51091469
ChEBI: 71028
LigandBox: D07130
KCF data

ATOM        13
            1   O6a O    14.9813  -16.8715
            2   C6a C    16.1938  -17.5716
            3   C1b C    17.4064  -16.8715
            4   C1b C    18.6189  -17.5716
            5   C1c C    19.8314  -16.8715
            6   C6a C    21.0440  -17.5716
            7   O6a O    22.2565  -16.8715
            8   O6a O    16.1938  -18.9715
            9   O6a O    21.0440  -18.9714
            10  N1b N    19.8314  -15.4715
            11  C5a C    18.6000  -14.7699
            12  O5a O    18.6017  -13.3698
            13  N1a N    17.4047  -15.4638
BOND        12
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     6   7 1
            7     2   8 2
            8     6   9 2
            9     5  10 1 #Down
            10   10  11 1
            11   11  12 2
            12   11  13 1

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Ontology (9)   
   KEGG BRITE (9)   
Disease (5)   
   KEGG DISEASE (5)   
Drug (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (4)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
All databases (22)   

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