| Entry |
|
|---|
| Name |
Palonosetron (INN);
Aloxi (TN) |
|---|
| Formula |
C19H24N2O
|
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| Exact mass |
296.1889
|
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| Mol weight |
296.4067
|
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| Structure |
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| Simcomp |
|
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| Class |
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG00064): | D05343<JP/US> |
| Product (mixture): | D10572<US> |
|
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| Efficacy |
Anti-emetic, Serotonin 5-HT3 receptor antagonist |
|---|
| Target |
|
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| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544], CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Interaction |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A04 ANTIEMETICS AND ANTINAUSEANTS
A04A ANTIEMETICS AND ANTINAUSEANTS
A04AA Serotonin (5HT3) antagonists
A04AA05 Palonosetron
D07175 Palonosetron (INN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00064 Palonosetron
D07175 Palonosetron
DG01762 Antiemetic
DG00064 Palonosetron
D07175 Palonosetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00064 Palonosetron
D07175 Palonosetron
DG01644 CYP2D6 substrate
DG00064 Palonosetron
D07175 Palonosetron
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00064 Palonosetron
D07175 Palonosetron
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Serotonin
HTR3
D07175 Palonosetron (INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D07175
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07175
Drug groups [BR:br08330]
Gastrointestinal agent
DG01489 5-HT3-receptor antagonist
DG00064 Palonosetron
DG01762 Antiemetic
DG00064 Palonosetron
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00064 Palonosetron
DG01644 CYP2D6 substrate
DG00064 Palonosetron
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00064 Palonosetron
|
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| Other DBs |
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| KCF data |
ATOM 22
1 N1y N 24.6400 -19.7400
2 C5x C 26.0400 -19.7400
3 C8y C 26.7400 -18.5500
4 C8y C 26.0400 -17.3600
5 C1y C 24.6400 -17.3600
6 C1x C 23.9400 -18.4800
7 C8y C 26.7400 -16.1700
8 C1x C 26.0400 -14.9100
9 C1x C 24.7100 -14.9100
10 C1x C 24.0100 -16.1000
11 C8x C 28.1400 -18.5500
12 C8x C 28.8400 -17.3600
13 C8x C 28.1400 -16.1700
14 O5x O 26.7400 -20.9300
15 C1y C 23.1700 -19.1800
16 C1x C 22.5400 -20.1600
17 N1y N 21.0700 -19.3200
18 C1x C 21.0700 -18.0600
19 C1x C 19.5300 -20.0900
20 C1y C 21.8400 -18.2700
21 C1x C 21.8400 -17.2900
22 C1x C 20.2300 -18.9700
BOND 26
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 3 11 1
13 11 12 2
14 12 13 1
15 13 7 2
16 2 14 2
17 16 17 1
18 16 15 1
19 17 18 1
20 17 19 1
21 15 20 1
22 18 21 1
23 19 22 1
24 20 21 1
25 20 22 1
26 15 1 1 #Down
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