| Entry |
|
|---|
| Name |
Amantadine (INN) |
|---|
| Formula |
C10H17N
|
|---|
| Exact mass |
151.1361
|
|---|
| Mol weight |
151.2487
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG03029 Anti-influenza virus agent
DG02841 Viral uncoating inhibitor
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG01967 Antiparkinson agent
Transporter substrate
DG02854 SLC22A2 substrate
|
|---|
| Remark |
| Product (DG00860): | D00777<JP/US> |
|
|---|
| Efficacy |
Antiviral, M2 protein inhibitor, Antiparkinsonian, Dopamine secretagogue |
|---|
| Comment |
Adamantane derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Transporter: SLC22A2 [HSA: 6582]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07235 | N-Methyl-D-aspartic acid (NMDA) receptor antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N04 ANTI-PARKINSON DRUGS
N04B DOPAMINERGIC AGENTS
N04BB Adamantane derivatives
N04BB01 Amantadine
D07441 Amantadine (INN)
Drug groups [BR:br08330]
Antiviral
DG03029 Anti-influenza virus agent
DG02841 Viral uncoating inhibitor
DG00860 Amantadine
D07441 Amantadine
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG00860 Amantadine
D07441 Amantadine
DG01967 Antiparkinson agent
DG00860 Amantadine
D07441 Amantadine
Transporter substrate
DG02854 SLC22A2 substrate
DG00860 Amantadine
D07441 Amantadine
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
Glutamate (ionotropic), NMDA
GRIN (NMDAR)
D07441 Amantadine (INN)
Antimicrobials [BR:br08307]
Antivirals
Entry, fusion or uncoating inhibitor
Influenza virus uncoating inhibitor
D07441 Amantadine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug transporters
D07441
Drug groups [BR:br08330]
Antiviral
DG03029 Anti-influenza virus agent
DG02841 Viral uncoating inhibitor
DG00860 Amantadine
Neuropsychiatric agent
DG01498 NMDA receptor antagonist
DG00860 Amantadine
DG01967 Antiparkinson agent
DG00860 Amantadine
Transporter substrate
DG02854 SLC22A2 substrate
DG00860 Amantadine
Antimicrobials abbreviations [BR:br08327]
Antivirals
Entry, fusion or uncoating inhibitor
Influenza virus uncoating inhibitor
DG00860 Amantadine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 11
1 C1z C 24.7800 -16.7300
2 C1x C 23.7300 -17.3600
3 C1x C 24.1500 -18.2000
4 C1x C 25.8300 -17.3600
5 N1a N 24.7800 -15.5400
6 C1y C 23.7300 -18.5500
7 C1y C 24.1500 -19.3200
8 C1y C 25.8300 -18.5500
9 C1x C 22.4700 -19.8100
10 C1x C 24.7800 -19.1800
11 C1x C 25.3400 -20.3700
BOND 13
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 3 7 1
7 4 8 1
8 6 9 1
9 6 10 1
10 7 11 1
11 7 9 1
12 8 10 1
13 8 11 1
|
|---|
