| Entry |
|
|---|
| Name |
Amlodipine (USP/INN);
Norvasc (TN) |
|---|
| Formula |
C20H25ClN2O5
|
|---|
| Exact mass |
408.1452
|
|---|
| Mol weight |
408.8759
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00322): | D00615<JP/US> D11881<US> |
| Product (mixture): | D10805<JP> D11069<US> |
|
|---|
| Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
|---|
| Comment |
Dihydropyridine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C08 CALCIUM CHANNEL BLOCKERS
C08C SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
C08CA Dihydropyridine derivatives
C08CA01 Amlodipine
D07450 Amlodipine (USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00322 Amlodipine
D07450 Amlodipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00322 Amlodipine
D07450 Amlodipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00322 Amlodipine
D07450 Amlodipine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D07450 Amlodipine (USP/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07450
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG00322 Amlodipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG00322 Amlodipine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00322 Amlodipine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C1y C 22.9600 -16.8000
2 C2y C 24.1500 -16.1000
3 C2y C 21.7700 -16.1000
4 C8y C 22.9600 -19.1800
5 C2y C 24.1500 -14.7000
6 C7a C 25.3400 -16.8000
7 C2y C 21.7700 -14.7000
8 C7a C 20.5800 -16.7300
9 C8y C 24.1500 -19.8800
10 C8x C 21.7700 -19.8800
11 N1x N 22.9600 -14.0000
12 C1b C 25.3400 -14.0000
13 O7a O 26.5300 -16.1000
14 O6a O 25.3400 -18.1300
15 C1a C 20.5800 -14.0000
16 O7a O 19.3900 -16.1000
17 O6a O 20.5800 -18.1300
18 C8x C 24.1500 -21.2100
19 X Cl 25.3400 -19.1800
20 C8x C 21.7700 -21.2100
21 O2a O 26.5300 -14.7000
22 C1b C 27.7200 -16.8000
23 C1a C 18.2000 -16.7300
24 C8x C 22.9600 -21.9100
25 C1b C 27.7200 -14.0000
26 C1a C 28.9100 -16.1000
27 C1b C 28.9100 -14.7000
28 N1a N 30.1000 -14.0000
BOND 29
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 4 10 2
10 5 11 1
11 5 12 1
12 6 13 1
13 6 14 2
14 7 15 1
15 8 16 1
16 8 17 2
17 9 18 2
18 9 19 1
19 10 20 1
20 12 21 1
21 13 22 1
22 16 23 1
23 18 24 1
24 21 25 1
25 22 26 1
26 25 27 1
27 27 28 1
28 7 11 1
29 20 24 2
|
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