| Entry |
|
|---|
| Name |
Apraclonidine (INN);
Iopidine (TN) |
|---|
| Formula |
C9H10Cl2N4
|
|---|
| Exact mass |
244.0283
|
|---|
| Mol weight |
245.1085
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
|
|---|
| Remark |
| Product (DG01130): | D01008<JP/US> |
|
|---|
| Efficacy |
Antiglaucoma, Antihypertensive (intraocular), alpha2-Adrenergic receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
S01EA Sympathomimetics in glaucoma therapy
S01EA03 Apraclonidine
D07461 Apraclonidine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG01130 Apraclonidine
D07461 Apraclonidine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01130 Apraclonidine
D07461 Apraclonidine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA2
D07461 Apraclonidine (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01450 alpha-Adrenergic receptor agonist
DG01449 alpha2-Adrenergic receptor agonist
DG01130 Apraclonidine
Ophthalmic agent
DG03201 Intraocular pressure lowering agent
DG01130 Apraclonidine
|
|---|
| Other DBs |
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|---|
| KCF data |
ATOM 15
1 C8x C 18.1300 -16.7300
2 C8y C 18.1300 -18.1300
3 C8x C 19.3200 -18.8300
4 C8y C 20.5800 -18.1300
5 C8y C 20.5800 -16.7300
6 C8y C 19.3200 -16.0300
7 X Cl 21.7700 -18.8300
8 N2x N 22.9600 -18.1300
9 C2y C 22.9600 -16.7300
10 N1b N 21.7700 -16.0300
11 C1x C 24.2900 -18.5500
12 C1x C 25.1300 -17.4300
13 N1x N 24.2900 -16.3100
14 X Cl 19.3200 -14.6300
15 N1a N 16.9400 -18.8300
BOND 16
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 8 9 2
9 9 10 1
10 5 10 1
11 8 11 1
12 11 12 1
13 12 13 1
14 9 13 1
15 6 14 1
16 2 15 1
|
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