| Entry |
|
|---|
| Name |
Paramethasone (INN);
Dillar (TN) |
|---|
| Formula |
C22H29FO5
|
|---|
| Exact mass |
392.1999
|
|---|
| Mol weight |
392.4611
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
|
|---|
| Efficacy |
Anti-inflammatory, Immunosuppressant, Glucocorticoid receptor agonist |
|---|
| Comment |
fluorinated steroid
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H02 CORTICOSTEROIDS FOR SYSTEMIC USE
H02A CORTICOSTEROIDS FOR SYSTEMIC USE, PLAIN
H02AB Glucocorticoids
H02AB05 Paramethasone
D07464 Paramethasone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00508 Paramethasone
D07464 Paramethasone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07464 Paramethasone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00508 Paramethasone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 28
1 C2x C 18.8300 -28.6300
2 C5x C 18.8300 -29.9600
3 C2x C 20.0200 -30.6600
4 C2y C 21.1400 -29.9600
5 C1z C 21.1400 -28.6300
6 C2x C 20.0200 -28.0000
7 C1y C 22.3300 -30.6600
8 C1x C 23.5200 -29.9600
9 C1y C 23.5200 -28.6300
10 C1y C 22.3300 -28.0000
11 C1y C 24.5700 -28.0000
12 C1z C 24.5700 -26.6700
13 C1x C 23.5200 -25.9700
14 C1y C 22.3300 -26.6700
15 C1x C 26.8800 -28.0000
16 C1y C 26.8800 -26.6700
17 C1z C 25.6900 -25.9700
18 O5x O 17.7100 -30.6600
19 C1a C 21.1400 -27.3000
20 O1a O 21.1400 -25.9700
21 C1a C 24.5700 -25.2700
22 C5a C 25.6900 -24.1500
23 O1a O 27.0900 -25.0600
24 C1a C 28.2800 -26.6700
25 X F 22.3300 -32.0600
26 O5a O 26.8800 -23.4500
27 C1b C 24.5000 -23.4500
28 O1a O 23.3100 -24.1500
BOND 31
1 1 2 1
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 9 11 1
13 11 12 1
14 12 13 1
15 13 14 1
16 10 14 1
17 11 15 1
18 15 16 1
19 16 17 1
20 12 17 1
21 2 18 2
22 5 19 1 #Up
23 14 20 1 #Up
24 12 21 1 #Up
25 17 22 1 #Up
26 17 23 1 #Down
27 16 24 1 #Down
28 7 25 1 #Down
29 22 26 2
30 22 27 1
31 27 28 1
|
|---|
