| Entry |
|
|---|
| Name |
Atazanavir (INN);
Reyataz (TN) |
|---|
| Formula |
C38H52N6O7
|
|---|
| Exact mass |
704.3897
|
|---|
| Mol weight |
704.8555
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
| Product (DG00657): | D01276<JP/US> |
| Product (mixture): | D10753<US> |
|
|---|
| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
Enzyme inhibition: UGT1A1 [HSA: 54658]
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE08 Atazanavir
D07471 Atazanavir (INN)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00657 Atazanavir
D07471 Atazanavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00657 Atazanavir
D07471 Atazanavir
DG02887 UGT1A1 inhibitor
DG00657 Atazanavir
D07471 Atazanavir
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D07471 Atazanavir (INN)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D07471
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07471
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00657 Atazanavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00657 Atazanavir
DG02887 UGT1A1 inhibitor
DG00657 Atazanavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
DG00657 Atazanavir
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 51
1 C1b C 28.7700 -21.7700
2 C1a C 17.1500 -24.0800
3 O7a O 18.3400 -24.7800
4 C7a C 19.4600 -24.0800
5 N1b N 20.6500 -24.7800
6 C1c C 21.8400 -24.0800
7 C5a C 22.9600 -24.7800
8 N1b N 24.1500 -24.0800
9 C1c C 25.2700 -24.7800
10 C1c C 26.4600 -24.0800
11 C1b C 27.6500 -24.7800
12 N1c N 28.7700 -24.0800
13 N1b N 29.9600 -24.7800
14 C5a C 31.0800 -24.0800
15 C1c C 32.2700 -24.7800
16 N1b N 33.3900 -24.0800
17 C7a C 34.5800 -24.7800
18 O7a O 35.7700 -24.0800
19 C1a C 36.8900 -24.7800
20 O6a O 19.4600 -22.7500
21 C1d C 21.8400 -21.5600
22 C1a C 21.8400 -20.2300
23 O5a O 22.9600 -26.1100
24 C1b C 25.2700 -26.1100
25 C8y C 26.4600 -26.7400
26 C8x C 26.4600 -28.1400
27 C8x C 27.6500 -28.7700
28 C8x C 28.7700 -28.1400
29 C8x C 28.7700 -26.7400
30 C8x C 27.6500 -26.1100
31 O1a O 26.4600 -22.7500
32 O5a O 31.0800 -22.7500
33 C1d C 32.2700 -27.0200
34 C1a C 32.2700 -28.4200
35 O6a O 34.5800 -26.1100
36 C1a C 23.1700 -21.5600
37 C1a C 20.4400 -21.5600
38 C8y C 29.9600 -21.1400
39 C8x C 31.0800 -21.7700
40 C8x C 32.2700 -21.0700
41 C8y C 32.2700 -19.7400
42 C8x C 31.1500 -19.0400
43 C8x C 29.9600 -19.7400
44 C8y C 33.4600 -19.0400
45 N5x N 34.6500 -19.7400
46 C8x C 35.8400 -19.0400
47 C8x C 35.8400 -17.7100
48 C8x C 34.6500 -17.0100
49 C8x C 33.4600 -17.7100
50 C1a C 33.6000 -27.0200
51 C1a C 30.8700 -27.0200
BOND 53
1 21 22 1
2 8 9 1
3 7 23 2
4 9 24 1 #Down
5 9 10 1
6 24 25 1
7 10 11 1
8 11 12 1
9 2 3 1
10 25 26 2
11 26 27 1
12 27 28 2
13 28 29 1
14 29 30 2
15 30 25 1
16 12 13 1
17 10 31 1 #Up
18 12 1 1
19 14 32 2
20 13 14 1
21 15 33 1 #Up
22 3 4 1
23 14 15 1
24 33 34 1
25 15 16 1
26 17 35 2
27 4 5 1
28 16 17 1
29 17 18 1
30 5 6 1
31 18 19 1
32 4 20 2
33 6 7 1
34 6 21 1 #Up
35 7 8 1
36 21 36 1
37 21 37 1
38 1 38 1
39 38 39 2
40 39 40 1
41 40 41 2
42 41 42 1
43 42 43 2
44 38 43 1
45 41 44 1
46 44 45 2
47 45 46 1
48 46 47 2
49 47 48 1
50 48 49 2
51 44 49 1
52 33 50 1
53 33 51 1
|
|---|
