| Entry |
|
|---|
| Name |
Atomoxetine (USP/INN);
Tomoxetine |
|---|
| Formula |
C17H21NO
|
|---|
| Exact mass |
255.1623
|
|---|
| Mol weight |
255.3547
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
|
|---|
| Remark |
| Product (DG00970): | D02574<JP/US> |
|
|---|
| Efficacy |
Stimulant (central), Selective noradrenaline reuptake inhibitor (NRI) |
|---|
| Comment |
Fluoxetine derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
N06BA Centrally acting sympathomimetics
N06BA09 Atomoxetine
D07473 Atomoxetine (USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00970 Atomoxetine
D07473 Atomoxetine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00970 Atomoxetine
D07473 Atomoxetine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D07473 Atomoxetine (USP/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07473
Drug groups [BR:br08330]
Neuropsychiatric agent
DG03085 Selective norepinephrine reuptake inhibitor (NRI)
DG00970 Atomoxetine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00970 Atomoxetine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C8x C 19.3200 -16.8700
2 C8x C 19.3200 -18.2700
3 C8x C 20.5100 -18.9700
4 C8x C 21.7700 -18.2700
5 C8y C 21.7700 -16.8700
6 C8y C 20.5100 -16.1700
7 C1a C 20.5100 -14.7700
8 O2a O 22.9600 -16.1700
9 C1c C 24.2200 -16.8700
10 C1b C 25.4100 -16.1700
11 C1b C 26.6000 -16.8700
12 N1b N 27.8600 -16.1700
13 C1a C 29.0500 -16.8700
14 C8y C 24.2200 -18.2700
15 C8x C 23.0300 -18.9700
16 C8x C 23.0300 -20.3700
17 C8x C 24.2200 -21.0700
18 C8x C 25.4100 -20.3700
19 C8x C 25.4100 -18.9700
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 5 8 1
9 8 9 1
10 9 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 9 14 1 #Down
15 14 15 2
16 15 16 1
17 16 17 2
18 17 18 1
19 18 19 2
20 14 19 1
|
|---|
