| Entry |
|
|---|
| Name |
Benazepril (INN);
Benazepril Sandoz (TN);
Forteekor [veterinary] (TN) |
|---|
| Formula |
C24H28N2O5
|
|---|
| Exact mass |
424.1998
|
|---|
| Mol weight |
424.4895
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
Metabolizing enzyme substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Product (DG00339): | D00620<JP/US> |
| Product (mixture): | D11069<US> |
|
|---|
| Efficacy |
Antihypertensive, Angiotensin-converting enzyme inhibitor |
|---|
| Comment |
Active form of prodrug: Benazeprilat [DR: D03077]
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07217 | Renin-angiotensin system inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C09 AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
C09A ACE INHIBITORS, PLAIN
C09AA ACE inhibitors, plain
C09AA07 Benazepril
D07499 Benazepril (INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
D07499 Benazepril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
D07499 Benazepril
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00339 Benazepril
D07499 Benazepril
Target-based classification of drugs [BR:br08310]
Enzymes
Hydrolases (EC3)
Peptidyl-dipeptidases
ACE (CD143)
D07499 Benazepril (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07499
Prodrugs [br08324.html]
D07499
Drug groups [BR:br08330]
Cardiovascular agent
DG01925 Renin-angiotensin system inhibitor
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
DG03231 Antihypertensive
DG01501 Angiotensin-converting enzyme inhibitor
DG00339 Benazepril
Metabolizing enzyme substrate
DG02924 UGT substrate
DG00339 Benazepril
Prodrugs [br08324.html]
DG00339
|
|---|
| Other DBs |
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|---|
| KCF data |
ATOM 31
1 C1x C 20.1600 -19.3900
2 C8y C 19.2500 -18.2700
3 C8y C 19.5300 -16.9400
4 N1y N 20.7900 -16.3100
5 C1x C 21.5600 -19.3900
6 C5x C 22.0500 -16.8700
7 C1y C 22.4000 -18.2000
8 C8x C 18.4800 -15.9600
9 C8x C 17.1500 -16.4500
10 C8x C 16.8700 -17.7800
11 C8x C 17.9200 -18.6900
12 C1b C 20.7200 -14.9100
13 C6a C 21.9100 -14.1400
14 O6a O 23.1700 -14.8400
15 O6a O 21.9800 -12.8100
16 O5x O 23.1700 -15.9600
17 N1b N 23.8000 -18.2000
18 C1c C 24.5000 -19.4600
19 C1b C 25.9000 -19.4600
20 C7a C 23.8000 -20.6500
21 C1b C 26.6000 -18.2000
22 C8y C 28.0000 -18.2000
23 O6a O 22.4000 -20.6500
24 O7a O 24.5000 -21.8400
25 C1b C 25.9000 -21.8400
26 C1a C 26.6000 -23.0300
27 C8x C 28.7000 -19.4600
28 C8x C 30.1000 -19.4600
29 C8x C 30.8000 -18.2700
30 C8x C 30.1000 -17.0100
31 C8x C 28.7000 -17.0100
BOND 33
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 4 12 1
14 12 13 1
15 13 14 1
16 13 15 2
17 6 16 2
18 7 17 1 #Up
19 17 18 1
20 18 19 1 #Up
21 18 20 1
22 19 21 1
23 21 22 1
24 20 23 2
25 20 24 1
26 24 25 1
27 25 26 1
28 22 27 2
29 27 28 1
30 28 29 2
31 29 30 1
32 30 31 2
33 22 31 1
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