| Entry |
|
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| Name |
Buclizine (INN);
Buclina (TN) |
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| Formula |
C28H33ClN2
|
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| Exact mass |
432.2332
|
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| Mol weight |
433.028
|
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| Structure |
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| Simcomp |
|
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| Class |
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
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| Remark |
|
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| Efficacy |
Antiallergic, H1 receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04750 | Inflammatory mediator regulation of TRP channels |
|
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| Interaction |
|
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| Structure map |
| map07212 | Histamine H1 receptor antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AE Piperazine derivatives
R06AE01 Buclizine
D07547 Buclizine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01104 Buclizine
D07547 Buclizine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D07547 Buclizine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG01104 Buclizine
|
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| Other DBs |
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| KCF data |
ATOM 31
1 C1c C 22.1900 -21.4200
2 N1y N 22.1900 -20.0200
3 C8y C 20.9300 -22.1200
4 C8y C 23.3800 -22.1200
5 C1x C 20.9300 -19.3200
6 C1x C 23.3800 -19.3200
7 C8x C 20.9300 -23.5200
8 C8x C 19.7400 -21.4200
9 C8x C 23.3800 -23.5200
10 C8x C 24.5700 -21.4200
11 C1x C 20.9300 -17.9200
12 C1x C 23.3800 -17.9200
13 C8x C 19.7400 -24.2200
14 C8x C 18.5500 -22.1200
15 C8x C 24.5700 -24.2200
16 C8x C 25.8300 -22.1200
17 N1y N 22.1900 -17.2200
18 C8y C 18.5500 -23.5200
19 C8x C 25.8300 -23.5200
20 C1b C 22.1900 -15.8200
21 X Cl 17.2900 -24.2200
22 C8y C 23.3800 -15.1200
23 C8x C 24.5700 -15.8200
24 C8x C 23.3800 -13.7200
25 C8x C 25.8300 -15.1200
26 C8x C 24.5700 -13.0200
27 C8y C 25.8300 -13.7200
28 C1d C 27.0200 -13.0200
29 C1a C 27.0200 -11.6200
30 C1a C 27.7200 -14.2100
31 C1a C 28.3500 -12.6700
BOND 34
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 2
9 4 10 1
10 5 11 1
11 6 12 1
12 7 13 2
13 8 14 1
14 9 15 1
15 10 16 2
16 11 17 1
17 13 18 1
18 15 19 2
19 17 20 1
20 18 21 1
21 20 22 1
22 22 23 2
23 22 24 1
24 23 25 1
25 24 26 2
26 25 27 2
27 27 28 1
28 28 29 1
29 28 30 1
30 28 31 1
31 12 17 1
32 14 18 2
33 16 19 1
34 26 27 1
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