| Entry |
|
|---|
| Name |
Bupivacaine (USAN/INN);
Bucaine (TN);
Exparel (TN) |
|---|
| Product |
|
|---|
| Formula |
C18H28N2O
|
|---|
| Exact mass |
288.2202
|
|---|
| Mol weight |
288.4277
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Product (DG00801): | D07552<US> D01450<JP/US> |
| Product (mixture): | D12270<US> |
|
|---|
| Efficacy |
Anesthetic (local) |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N01 ANESTHETICS
N01B ANESTHETICS, LOCAL
N01BB Amides
N01BB01 Bupivacaine
D07552 Bupivacaine (USAN/INN) <US>
USP drug classification [BR:br08302]
Anesthetics
Local Anesthetics
Bupivacaine
D07552 Bupivacaine (USAN/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00801 Bupivacaine
D07552 Bupivacaine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00801 Bupivacaine
D07552 Bupivacaine
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Sodium channels
SCN1A
D07552 Bupivacaine (USAN/INN) <US>
SCN2A
D07552 Bupivacaine (USAN/INN) <US>
SCN3A
D07552 Bupivacaine (USAN/INN) <US>
SCN4A
D07552 Bupivacaine (USAN/INN) <US>
SCN5A
D07552 Bupivacaine (USAN/INN) <US>
SCN8A
D07552 Bupivacaine (USAN/INN) <US>
SCN9A
D07552 Bupivacaine (USAN/INN) <US>
SCN10A
D07552 Bupivacaine (USAN/INN) <US>
SCN11A
D07552 Bupivacaine (USAN/INN) <US>
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D07552
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07552
Drug groups [BR:br08330]
Neuropsychiatric agent
DG02030 Anesthetics
DG01675 Local anesthetic
DG01673 Amide type local anesthetic
DG00801 Bupivacaine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00801 Bupivacaine
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 21
1 C1y C 25.9700 -17.6400
2 N1y N 25.9700 -19.0400
3 C5a C 24.7800 -16.9400
4 C1b C 24.7800 -19.7400
5 N1b N 23.5900 -17.6400
6 O5a O 24.7800 -15.5400
7 C1b C 23.5900 -19.0400
8 C8y C 22.4000 -16.8700
9 C1b C 22.3300 -19.7400
10 C8y C 21.1400 -17.5700
11 C8y C 22.4000 -15.4700
12 C1a C 22.3300 -21.0700
13 C8x C 19.9500 -16.8700
14 C1a C 21.1400 -18.9700
15 C8x C 21.1400 -14.7700
16 C8x C 19.9500 -15.4700
17 C1a C 23.5900 -14.7700
18 C1x C 27.1600 -19.7400
19 C1x C 28.4200 -19.0400
20 C1x C 28.4200 -17.6400
21 C1x C 27.2300 -16.9400
BOND 22
1 1 2 1
2 1 3 1
3 2 4 1
4 3 5 1
5 3 6 2
6 4 7 1
7 5 8 1
8 7 9 1
9 8 10 1
10 8 11 2
11 9 12 1
12 10 13 2
13 10 14 1
14 11 15 1
15 13 16 1
16 15 16 2
17 11 17 1
18 2 18 1
19 18 19 1
20 19 20 1
21 20 21 1
22 1 21 1
|
|---|
