| Entry |
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| Name |
Cerivastatin (INN) |
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| Formula |
C26H34FNO5
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| Exact mass |
459.2421
|
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| Mol weight |
459.5503
|
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| Structure |
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| Simcomp |
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| Class |
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
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| Remark |
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| Efficacy |
Antihyperlipidemic, HMG-CoA reductase inhibitor |
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| Target |
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| Pathway |
| hsa00900 | Terpenoid backbone biosynthesis |
|
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| Metabolism |
Enzyme: CYP2C8 [HSA: 1558], CYP3A4 [HSA: 1576]
|
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| Interaction |
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| Structure map |
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| Other map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C10 LIPID MODIFYING AGENTS
C10A LIPID MODIFYING AGENTS, PLAIN
C10AA HMG CoA reductase inhibitors
C10AA06 Cerivastatin
D07661 Cerivastatin (INN)
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00356 Cerivastatin
D07661 Cerivastatin
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00356 Cerivastatin
D07661 Cerivastatin
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00356 Cerivastatin
D07661 Cerivastatin
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
HMGCR
D07661 Cerivastatin (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07661
Drug groups [BR:br08330]
Hypolipidemic agent
DG01946 Hypolipidemic agent
DG01660 HMG-CoA reductase inhibitor
DG00356 Cerivastatin
Metabolizing enzyme substrate
DG02918 CYP2C8 substrate
DG00356 Cerivastatin
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00356 Cerivastatin
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| Other DBs |
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| KCF data |
ATOM 33
1 C8y C 21.7700 -17.8500
2 C8y C 21.7700 -19.3200
3 C8y C 20.5100 -17.2200
4 C8y C 22.9600 -17.1500
5 C8y C 20.5100 -20.0200
6 C2b C 22.9600 -19.9500
7 C8y C 19.3200 -17.9200
8 C1b C 20.5100 -15.7500
9 C8x C 24.1500 -17.8500
10 C8x C 22.9600 -15.7500
11 N5x N 19.3200 -19.3200
12 C1c C 20.5100 -21.4200
13 C2b C 24.1500 -19.2500
14 C1c C 18.1300 -17.2200
15 O2a O 19.3200 -15.1200
16 C8x C 25.3400 -17.1500
17 C8x C 24.1500 -15.0500
18 C1a C 19.3200 -22.1200
19 C1a C 21.7700 -22.1200
20 C1c C 25.3400 -19.9500
21 C1a C 18.1300 -15.7500
22 C1a C 16.8700 -17.9200
23 C1a C 19.3200 -13.7200
24 C8y C 25.3400 -15.7500
25 C1b C 26.6000 -19.2500
26 O1a O 25.3400 -21.3500
27 X F 26.6000 -15.0500
28 C1c C 27.7900 -19.9500
29 C1b C 28.9800 -19.2500
30 O1a O 27.7900 -21.3500
31 C6a C 30.2400 -19.9500
32 O6a O 30.2400 -21.3500
33 O6a O 31.4300 -19.2500
BOND 34
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 2
13 7 14 1
14 8 15 1
15 9 16 1
16 10 17 2
17 12 18 1
18 12 19 1
19 13 20 1
20 14 21 1
21 14 22 1
22 15 23 1
23 16 24 2
24 20 25 1
25 20 26 1 #Down
26 24 27 1
27 25 28 1
28 28 29 1
29 28 30 1 #Down
30 29 31 1
31 31 32 2
32 31 33 1
33 7 11 2
34 17 24 1
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