KEGG   DRUG: Cevimeline
Entry
D07667                      Drug                                   
Name
Cevimeline (INN)
Formula
C10H17NOS
Exact mass
199.1031
Mol weight
199.3131
Structure
Class
Neuropsychiatric agent
 DG01490  Muscarinic cholinergic receptor agonist
 DG01719  Parasympathomimetic agent
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
ATC code: N07AX03
Chemical structure group: DG00993
Product (DG00993): D00661<JP/US>
Efficacy
Salivation accelaletor, Muscarinic acetylcholine receptor agonist
Comment
Arecoline derivative
Target
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
hsa04970  Salivary secretion
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07A PARASYMPATHOMIMETICS
    N07AX Other parasympathomimetics
     N07AX03 Cevimeline
      D07667  Cevimeline (INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00993  Cevimeline
    D07667  Cevimeline
  DG01719  Parasympathomimetic agent
   DG00993  Cevimeline
    D07667  Cevimeline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00993  Cevimeline
    D07667  Cevimeline
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00993  Cevimeline
     D07667  Cevimeline
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM3
     D07667  Cevimeline (INN)
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D07667
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01490  Muscarinic cholinergic receptor agonist
   DG00993  Cevimeline
  DG01719  Parasympathomimetic agent
   DG00993  Cevimeline
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   DG00993  Cevimeline
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    DG00993  Cevimeline
Other DBs
CAS: 107233-08-9
PubChem: 51091969
ChEBI: 3568
LigandBox: D07667
NIKKAJI: J1.049.900C
KCF data

ATOM        13
            1   C1z C    24.2900  -17.4300
            2   C1y C    24.2900  -16.0300
            3   C1x C    23.0300  -18.2000
            4   C1x C    23.0300  -15.2600
            5   C1x C    23.4500  -16.8700
            6   N1y N    21.7700  -17.4300
            7   C1x C    21.7700  -16.0300
            8   C1x C    22.7500  -16.3800
            9   O2x O    24.2900  -18.8300
            10  C1y C    25.6900  -19.3200
            11  S2x S    26.5300  -18.1300
            12  C1x C    25.6900  -16.9400
            13  C1a C    26.1100  -20.6500
BOND        15
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     6   7 1
            9     6   8 1
            10    1   9 1 #Up
            11    9  10 1
            12   10  11 1
            13   11  12 1
            14    1  12 1
            15   10  13 1 #Down

» Japanese version   » Back

DBGET integrated database retrieval system