| Entry |
|
|---|
| Name |
Cyclophosphamide (INN);
Cyclophosphamide (TN);
Cytoxan (TN) |
|---|
| Formula |
C7H15Cl2N2O2P
|
|---|
| Exact mass |
260.0248
|
|---|
| Mol weight |
261.086
|
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| Structure |
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| Simcomp |
|
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| Class |
|
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| Remark |
| Product (DG00675): | D00287<JP/US> |
|
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| Efficacy |
Antineoplastic, Alkylating agent |
|---|
| Comment |
Active form of prodrug: 4-Hydroxycyclophosphamide [CPD: C07643]
|
|---|
| Target |
DNA |
|---|
| Metabolism |
Enzyme: CYP2B6 [HSA: 1555]; CYP2A6 [HSA: 1548], CYP2C8 [HSA: 1558], CYP2C9 [HSA: 1559], CYP3A4 [HSA: 1576]
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| Interaction |
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| Structure map |
| map07040 | Antineoplastics - alkylating agents |
| map07050 | Antirheumatics - DMARDs and biological agents |
|
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| Other map |
| map00982 | Drug metabolism - cytochrome P450 |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01A ALKYLATING AGENTS
L01AA Nitrogen mustard analogues
L01AA01 Cyclophosphamide
D07760 Cyclophosphamide (INN)
Drug groups [BR:br08330]
Antineoplastic
DG01677 Alkylating agent
DG01678 Nitrogen mustard analog
DG01720 Isophosphoramide mustard analog
DG00675 Cyclophosphamide
D07760 Cyclophosphamide
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00675 Cyclophosphamide
D07760 Cyclophosphamide
DG02919 CYP2B6 substrate
DG00675 Cyclophosphamide
D07760 Cyclophosphamide
DG02918 CYP2C8 substrate
DG00675 Cyclophosphamide
D07760 Cyclophosphamide
DG01642 CYP2C9 substrate
DG00675 Cyclophosphamide
D07760 Cyclophosphamide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00675 Cyclophosphamide
D07760 Cyclophosphamide
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07760
Prodrugs [br08324.html]
D07760
Drug groups [BR:br08330]
Antineoplastic
DG01677 Alkylating agent
DG01678 Nitrogen mustard analog
DG01720 Isophosphoramide mustard analog
DG00675 Cyclophosphamide
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00675 Cyclophosphamide
DG02919 CYP2B6 substrate
DG00675 Cyclophosphamide
DG02918 CYP2C8 substrate
DG00675 Cyclophosphamide
DG01642 CYP2C9 substrate
DG00675 Cyclophosphamide
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00675 Cyclophosphamide
Prodrugs [br08324.html]
DG00675
|
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| Other DBs |
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| KCF data |
ATOM 14
1 P1a P 23.6600 -17.8500
2 N1c N 23.6600 -16.3800
3 N1x N 24.7800 -18.4800
4 O2x O 22.5400 -18.4800
5 O3b O 22.4000 -17.1500
6 C1b C 22.4000 -15.6800
7 C1b C 24.9200 -15.6100
8 C1x C 24.7800 -19.8100
9 C1x C 22.5400 -19.8100
10 C1b C 21.1400 -16.5200
11 C1b C 26.1800 -16.2400
12 C1x C 23.6600 -20.4400
13 X Cl 19.8100 -15.8200
14 X Cl 27.4400 -15.4700
BOND 14
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 2
5 2 6 1
6 2 7 1
7 3 8 1
8 4 9 1
9 6 10 1
10 7 11 1
11 8 12 1
12 10 13 1
13 11 14 1
14 9 12 1
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