| Entry |
|
|---|
| Name |
Desvenlafaxine (INN);
Khedezla (TN) |
|---|
| Product |
|
|---|
| Formula |
C16H25NO2
|
|---|
| Exact mass |
263.1885
|
|---|
| Mol weight |
263.3752
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG02924 UGT substrate
|
|---|
| Remark |
| Product (DG00963): | D07793<US> D02570<US> D11619<US> |
|
|---|
| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
|---|
| Disease |
Major depressive disorder [DS: H01646] |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX23 Desvenlafaxine
D07793 Desvenlafaxine (INN) <US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Desvenlafaxine
D07793 Desvenlafaxine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
DG00963 Desvenlafaxine
D07793 Desvenlafaxine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00963 Desvenlafaxine
D07793 Desvenlafaxine
DG02924 UGT substrate
DG00963 Desvenlafaxine
D07793 Desvenlafaxine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D07793 Desvenlafaxine (INN) <US>
SLC6A4 (HTT)
D07793 Desvenlafaxine (INN) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07793
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01658 Serotonin and norepinephrine reuptake inhibitor (SNRI)
DG00963 Desvenlafaxine
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00963 Desvenlafaxine
DG02924 UGT substrate
DG00963 Desvenlafaxine
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 19
1 C8x C 24.5700 -22.3300
2 C8y C 24.5700 -23.7300
3 C8x C 25.7600 -24.4300
4 C8x C 26.9500 -23.7300
5 C8y C 26.9500 -22.3300
6 C8x C 25.7600 -21.6300
7 C1x C 29.4000 -23.7300
8 C1z C 29.4000 -22.3300
9 C1c C 28.1400 -21.6300
10 C1x C 30.5900 -24.4300
11 C1x C 31.7800 -23.7300
12 C1x C 31.7800 -22.3300
13 C1x C 30.5900 -21.6300
14 O1a O 23.3800 -24.4300
15 O1a O 29.3828 -20.9301
16 C1b C 28.1228 -20.2301
17 N1c N 26.9149 -19.5524
18 C1a C 25.6958 -20.2768
19 C1a C 26.8978 -18.1301
BOND 20
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 1
11 10 11 1
12 11 12 1
13 12 13 1
14 8 13 1
15 2 14 1
16 8 15 1
17 9 16 1
18 16 17 1
19 17 18 1
20 17 19 1
|
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