| Entry |
|
|---|
| Name |
Diflorasone (INN);
Murode (TN) |
|---|
| Formula |
C22H28F2O5
|
|---|
| Exact mass |
410.1905
|
|---|
| Mol weight |
410.4515
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
| Product (DG00418): | D01327<JP/US> |
|
|---|
| Efficacy |
Anti-inflammatory, Glucocorticoid receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
D07A CORTICOSTEROIDS, PLAIN
D07AC Corticosteroids, potent (group III)
D07AC10 Diflorasone
D07827 Diflorasone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00418 Diflorasone
D07827 Diflorasone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C1 (GR)
D07827 Diflorasone (INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01955 Corticosteroid
DG02068 Glucocorticoid
DG00418 Diflorasone
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 29
1 C1z C 26.1100 -16.8700
2 C1z C 24.9200 -17.5700
3 C1y C 27.2300 -17.5700
4 C5a C 26.1100 -15.0500
5 C1y C 24.9200 -18.9000
6 C1x C 23.8000 -16.8700
7 C1a C 24.9200 -16.1700
8 C1x C 27.2300 -18.9000
9 C1b C 24.9900 -14.3500
10 O5a O 27.3000 -14.4200
11 C1y C 23.8000 -19.5300
12 C1y C 22.6100 -17.5000
13 O1a O 23.8000 -15.0500
14 C1z C 22.6100 -18.8300
15 C1x C 23.8000 -20.8600
16 O1a O 21.4900 -16.8700
17 C1z C 21.4900 -19.5300
18 X F 22.6100 -20.1600
19 C1y C 22.6100 -21.4900
20 C2y C 21.4900 -20.8600
21 C2x C 20.3000 -18.8300
22 C1a C 21.4900 -18.2000
23 C2x C 20.3000 -21.4900
24 C2x C 19.1800 -19.5300
25 C5x C 19.1800 -20.8600
26 O5x O 17.9900 -21.4900
27 C1a C 28.6300 -17.5700
28 X F 22.6100 -22.8900
29 O1a O 27.3224 -16.1700
BOND 32
1 1 4 1 #Up
2 2 5 1
3 2 6 1
4 2 7 1 #Up
5 3 8 1
6 4 9 1
7 4 10 2
8 5 11 1
9 6 12 1
10 9 13 1
11 11 14 1
12 11 15 1
13 12 16 1 #Up
14 14 17 1
15 14 18 1 #Down
16 15 19 1
17 17 20 1
18 17 21 1
19 17 22 1 #Up
20 20 23 2
21 21 24 2
22 23 25 1
23 25 26 2
24 5 8 1
25 12 14 1
26 19 20 1
27 24 25 1
28 3 27 1 #Up
29 1 2 1
30 1 3 1
31 19 28 1 #Down
32 1 29 1 #Down
|
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